Structural Bioinformatics MCQs : Here you will find MCQ Questions related to "Structural Bioinformatics" in Bioinformatics. These Structural Bioinformatics MCQ Questions Will help you to improve your Bioinformatics knowledge and will prepare you for various Examinations like Competitive Exams, Placements, Interviews and other Entrance Exmaniations.
Question 1
Which is the legacy textual file format used to store information of three-dimensional structures of macromolecules?
A. .pdc
B. .pdb
C. .pdp
D. .pdz
View Answer
Ans : B
Explanation: The PDB format (.pdb) is the legacy textual file format used to store information of three-dimensional structures of macromolecules used by the Protein Data Bank.
Question 2
Structural alignment is a method for comparison between 3D structures based on their shape and conformation.
A. TRUE
B. FALSE
C. Can be true or false
D. Can not say
View Answer
Ans : A
Explanation: True, Structural alignment is a method for comparison between 3D structures based on their shape and conformation.
Question 3
Structural bioinformatics is the branch of bioinformatics that is related to the analysis and prediction of the ____________ structure of biological macromolecules.
A. one-dimensional
B. two-dimensional
C. three-dimensional
D. All of the above
View Answer
Ans : C
Explanation: Structural bioinformatics is the branch of bioinformatics that is related to the analysis and prediction of the three-dimensional structure of biological macromolecules.
Question 4
Example of Structural bioinformatics are?
A. proteins
B. RNA
C. DNA
D. All of the above
View Answer
Ans : D
Explanation: such as proteins, RNA, and DNA
Question 5
In general, protein structures are classified into ___________ levels
A. 1
B. 2
C. 3
D. 4
View Answer
Ans : D
Explanation: In general, protein structures are classified into four levels: primary (sequences), secondary (local conformation of the polypeptide chain), tertiary (three-dimensional structure of the protein fold), and quaternary (association of multiple polypeptide structures)
Question 6
______ the smallest amino acid, has a hydrogen atom as the R group.
A. valine
B. proline
C. Glycine
D. threonine
View Answer
Ans : C
Explanation: Of particular interest within the twenty amino acids are glycine and proline. It can therefore adopt more flexible conformations that are not possible for other amino acids. Proline is on the other extreme of flexibility. Its side chain forms a bond with its own backbone amino group, causing it to be cyclic. The cyclic conformation makes it very rigid, unable to occupy many of the main chain conformations adopted by other amino acids.
Question 7
Which of the following is wrong about Swiss-PDB Viewer?
A. It is a structure viewer for multiple platforms
B. It is a structure viewer for single platforms
C. It is essentially a Swiss-Army knife for structure visualization and modeling
D. It is capable of structure visualization, analysis, and homology modeling
View Answer
Ans : B
Explanation: It is essentially a Swiss-Army knife for structure visualization and modeling because it incorporates so many functions in a small shareware program. It allows display of multiple structures at the same time in different styles, by charge distribution, or by surface accessibility. It can measure distances, angles, and even mutate residues. In addition, it can calculate molecular surface, electrostatic potential, Ramachandran plot, and so on. The homology modeling part includes energy minimization and loop modeling.
Question 8
The intermolecular approach is normally applied to relatively _____ structures.
A. distinctive
B. dissimilar
C. different
D. similar
View Answer
Ans : D
Explanation: The algorithmic approaches to comparing protein geometric properties can be divided into three categories: the first superposes protein structures by minimizing intermolecular distances; the second relies on measuring intramolecular distances of a structure; and the third includes algorithms that combine both intermolecular and intramolecular approaches.
Question 9
Which of the following is untrue about SCOP?
A. It is a database for comparing and classifying protein structures
B. The SCOP families consist of proteins having low sequence identity
C. The proteins are grouped into hierarchies of classes, folds, superfamilies, and families
D. It is constructed almost entirely based on manual examination of protein structures
View Answer
Ans : B
Explanation: The SCOP families consist of proteins having high sequence identity (>30%). Thus, the proteins within a family clearly share close evolutionary relationships and normally have the same functionality. The protein structures at this level are also extremely similar
Question 10
Structural bioinformatics main objectives are the creation of new methods to deal with biological macromolecules data to solve problems in biology and generate new knowledge.
A. TRUE
B. FALSE
C. Can be true or false
D. Can not say
View Answer
Ans : A
Explanation: True, Structural bioinformatics main objectives are the creation of new methods to deal with biological macromolecules data to solve problems in biology and generate new knowledge