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Antibody MCQ Questions & Answers

Antibody MCQs : This section focuses on the "Antibody". These Multiple Choice Questions (MCQs) should be practiced to improve the Antibody skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

Self reactive antibodies are not found in significant concentration in normal serum because

A. it is impossible to generate a self-reactive antibody
B. self reactive B cells are killed by CD8 T cells
C. B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
D. self reactive B cells switch to IgA which is all secreted and not present in serum

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Question 2

Which of the following mediates Type I hypersensitivity reaction?

A. IgE
B. IgG
C. IgM
D. IgD

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Question 3

Which is not a function of IgA?

A. Protect mucosal surfaces
B. Fix complement
C. Protect eyes
D. Agglutinate antigen

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Question 4

Which is the most efficient complement fixing class of antibody?

A. IgE
B. IgA
C. IgM
D. IgG

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Question 5

The secretary component of sIgA is

A. made by plasma cells that secrete dimeric IgA
B. added to dimeric IgA by the M cell
C. formed by cleavage of an epithelial cell receptor used to transport the dimeric IgA across the epithelial cell
D. made by T cells

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Question 6

Heat-labile class of immunoglobulins include

A. IgA
B. IgE
C. IgG
D. IgM

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Question 7

Which of the following (s) is/are function (s) of Fc fragment of IgG?

A. It determines catabolic rate
B. It binds complement
C. It is related to passage of IgG across the placental barrier
D. All of these

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Question 8

Which of the following (s) is/are function (s) of Fc fragment of IgG?

A. It determines catabolic rate
B. It binds complement
C. It is related to passage of IgG across the placental barrier
D. All of the above

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Question 9

Which is not a function of IgG?

A. Major antibody in serum
B. First antibody type produced against an antigen during the primary antibody response
C. Activates or fixes complement
D. Involved in opsonization

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Question 10

Anti-Rh antibodies are

A. IgG type
B. IgA type
C. IgE type
D. IgD type

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Question 11

The class of immunoglobulin, most abundant in body is

A. IgD
B. IgE
C. IgG
D. IgM

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Question 12

Which of the following theory of antibody production is most widely accepted?

A. Side chain theory
B. Clonal selection theory
C. Direct template theory
D. Indirect template theory

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Question 13

J chain is present in

A. IgA
B. IgM
C. Both (a) and (b)
D. IgE

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Question 14

Which of the following is the phylogenetically oldest immunoglobulin?

A. IgE
B. IgM
C. IgG
D. All are similar

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Question 15

J chain is present in

A. IgA
B. IgM
C. Both A and B
D. IgE

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Question 16

Antigen binding sites of an immunoglobulin are located in

A. light chain alone
B. heavy chain alone
C. Fc region of the antibody
D. Fab regions of the antibody

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Question 17

Simulation of which of the following will lead to appearance of first antibody to appear following stimulation by an antigen?

A. IgM
B. IgA
C. IgE
D. IgG

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Question 18

The class of immunoglobulins which can cross the placenta is

A. IgM
B. IgG
C. IgA
D. IgD

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