Antimicrobial Chemotherapeutic Agents MCQs : This section focuses on the "Antimicrobial Chemotherapeutic Agents". These Multiple Choice Questions (MCQs) should be practiced to improve the Antimicrobial Chemotherapeutic Agents skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.
Question 1
Which of the following may cause resistance to penicillin?
A. Impermeability of cell envelope
B. Production of β-lactamases by bacteria
C. Alteration or lack of penicillin-binding proteins
D. All of the above
Question 2
Which antibiotic has a beta-lactam ring?
A. Cephalosporin
B. Penicillin
C. Tetracycline
D. Streptomycin
Question 3
A parenteral route of drug administration refers to
A. oral
B. nonoral
C. intravenously
D. intramuscularly
Question 4
Which of the following antibiotics can't be used for treatment of infections with β-lactamase-producing Staphylococcus aureus?
A. Vancomycin
B. Ampicillin/sulbactam
C. Cephalothin
D. Piperacillin
Question 5
Nystatin is a drug used for treatment of diseases caused by
A. gram negative bacterium
B. gram positive bacterium
C. yeast
D. protozoan
Question 6
The penicillin resistant to β-lactamases is
A. carbenicillin
B. closacillin
C. penicillin-G
D. ampicillin
Question 7
A broad-spectrum antibiotic such as chloramphenicol is one that
A. kills both Gram positive and Gram negative bacteria
B. kills all bacteria
C. kills numerous types of microbes
D. kills all microorganisms
Question 8
Which is not an amino acid and peptide antibiotic?
A. Penicillin
B. Actinomycin
C. Bacitracin
D. Tetranactin
Question 9
Chelate forming peptide antibiotic are/is
A. bleomycins
B. sideromycins
C. both (a) and (b)
D. vancomycin
Question 10
Which of the following is not an example of potent antitumer agents?
A. Anthramycin
B. Sibromycin
C. Neothramycin
D. Erythromycin
Question 11
Amphotericin B and polymyxin interfere with
A. cell wall synthesis
B. protein synthesis
C. cell membrane function
D. DNA function
Question 12
Which of the following group is not the carbohydrate containing antibiotic?
A. Streptomycin & Streptothricin
B. Vancomycin & Moenomycin
C. Everninomycin & Nogirimycin
D. Erythromycin & candicidin
Question 13
Which of the following is a drug that interferes with the process of DNA production in the virus that causes genital herpes?
A. Erythromycin
B. Vancomycin
C. Amantadine
D. Acyclovir
Question 14
Cycloserine inhibits
A. alanine racemase
B. D-alanyl - D-alanine synthetase
C. Both A and B
D. amidase
Question 15
The susceptibility of a microorganism to antibiotics and other chemotherapeutic agents can be determined by using
A. tube dilution technique
B. paper disk plate
C. both (a) and (b)
D. none of these
Question 16
Which of the following drugs involves modification of the drug by enzymatic modification or degradation of its active element to alter its/their resistance?
A. Pencillins
B. Choloramphenicol
C. Aminoglyosides
D. All of the above
Question 17
Who developed the concept of specific toxicity?
A. Pasteur
B. Fleming
C. Watson
D. Ehrlich
Question 18
The third generation cephalosporin agents is
A. cefotaxime
B. cefoxitin
C. cephalothin
D. cephalexin
Question 19
The scientist who first discovered the substance penicillin was
A. Joseph Lister
B. Alexander Fleming
C. Paul Ehrlich
D. none of these
Question 20
Quinolones are
A. antimetabolites
B. penicillin derivatives
C. bacteriostatic
D. broad-spectrum
Question 21
Which of the following methods would be most appropriate for sterilizing an antibiotic solution?
A. Dry heat sterilization
B. Microfiltration
C. Autoclaving
D. Desiccation
Question 22
Polyene antibiotics are
A. large ring structures
B. β-lactam - thiazolidine ring
C. small ring structures
D. any of these
Question 23
Which of the following tests is used to determine the minimal lethal concentration?
A. Broth dilution test
B. Agar dilution test
C. Dilution susceptibility tests
D. All of these
Question 24
Cycloserine inhibits
A. alanine racemase
B. D-alanyl - D-alanine synthetase
C. Both (a) and (b)
D. amidase
Question 25
The most selective antibiotics are those that interfere with the synthesis of
A. bacterial DNA
B. bacterial RNA
C. bacterial cell walls
D. bacterial plasma membrane
Question 26
Which of the following is not a semi synthetic chemotherapeutic agent?
A. Ampicillin
B. Carbenicillin
C. Penicillin
D. Sulfonamide
Question 27
Novobiocin can be used against
A. gram +ve Staphylococci
B. gram -ve Meningococci & Gonococci
C. Haemophilus
D. All of the above
Question 28
Which of the following is not an aminoglycoside antibiotic?
A. Streptomycin
B. Neomycin
C. Kanamycin
D. Cephalosporin
Question 29
Which of the following drugs involves modification of the drug by enzymatic modification or degradation of its active element to alter its/their resistance?
A. Pencillins
B. Choloramphenicol
C. Aminoglyosides
D. All of these
Question 30
Novobiocin can be used against
A. gram +ve Staphylococci
B. gram -ve Meningococci & Gonococci
C. Haemophilus
D. all of these
Question 31
Bacterial cells susceptible to penicillium can be protected from destruction if the medium in which they are exposed is of
A. high osmotic pressure
B. low osmotic pressure
C. moderate osmotic pressure
D. high surface tension
Question 32
Chemotherapeutic agents must
A. prevent/destroy the activity of a parasite
B. leave unaltered the host's natural defense mechanisms
C. be able to come in contact with the parasite by penetrating the cells
D. All of the above
Question 33
Cephalosporins and Penicillins interfere with which of the following?
A. Protein synthesis
B. DNA function
C. Cell membrane function
D. Cell wall synthesis
Question 34
The compound(s) which act(s) as metabolic antagonist is/are
A. trimethoprim
B. sulphonamides
C. both (a) and (b)
D. none of these
Question 35
Which of the following is used only in life-threatening situations when no other drug is adequate?
A. Penicillin
B. Tetracycline
C. Chloramphenicol
D. Streptomycin
Question 36
The antibiotics not clinically useful for Pseudomonas aeruginosa infection is
A. aminoglycosides
B. ceftazidime
C. piperacillin
D. trimethoprim-sulphamethoxazole
Question 37
Which of the antibiotic is not used as a food preservative ?
A. Pimaricin
B. Nisin
C. Tylosin
D. β-lactam antibiotic
Question 38
Interference mechanism of ciprofloxacin and norfloxacin is due to their action on
A. cell wall synthesis
B. cell membrane function
C. DNA function
D. protein synthesis
Question 39
The mode of action of polymyxin is to
A. inhibit protein synthesis
B. inhibit DNA synthesis
C. injury to the plasma membrane
D. inhibit folic acid synthesis
Question 40
Which of the following protein synthesis mechanisms may be affected by particular drugs?
A. Peptide bond formation
B. mRNA translocation
C. Aminoacyl-tRNA binding
D. All of these
Question 41
Quinones and related antibiotics are
A. tetracyclines
B. actinorhodin
C. mitomycin
D. all of these
Question 42
More promising chemotherapeutic agents for treating viral diseases is
A. leukocytic interferon
B. fibroblast interferon
C. interferon
D. nystatin
Question 43
The antibiotics not having good activity against Enterobacteriaceae is
A. clindamycin
B. cefoxitin
C. trimethoprim-sulphamethoxazole
D. ciprofloxacin
Question 44
With which of the following aminoglycosides interfere?
A. Protein synthesis
B. DNA function
C. Cell wall synthesis
D. Cell membrane function
Question 45
Which of the following drugs may show plasmid-mediated resistance?
A. Nalidixic acid
B. Ampicillin
C. Rifampicin
D. Methicillin
Question 46
The penicillin stable in gastric acid and suitable for oral administration is
A. methicillin
B. carbenicillin
C. closacillin
D. pencillin-G
Question 47
Most antibiotics are isolated from
A. viruses
B. aquatic microorganisms
C. soil microorganisms
D. plants
Question 48
When using alcohol as an antiseptic, which concentration is considered most effective?
A. 95%
B. 50%
C. 70%
D. 25%
Question 49
By which of the following means antifungal chemotherapeutic agents may affect fungi?
A. Interfere with nuclear division by preventing the aggregation of microtubules needed for mitosis
B. Interfere with normal nucleic acid synthesis
C. Interfere with ergosterol biosynthesis and thus alter the structure of the cytoplasmic membrane as well as the function of several membrane-bound enzymes like those involved in nutrient transport and chitin synthesis
D. all of these
Question 50
Vancomycin inhibits peptidoglycan synthesis by binding
A. D-alanyl - D-alanine
B. alanine racemase
C. D-alanyl - D-alanine synthetase
D. amidase
Question 51
The nitrofurans differ from the antibiotics in that they
A. do not occur naturally
B. occur naturally
C. are antimicrobial drugs
D. all of these
Question 52
By which of the following means antifungal chemotherapeutic agents may affect fungi?
A. Interfere with nuclear division by preventing the aggregation of microtubules needed for mitosis
B. Interfere with normal nucleic acid synthesis
C. Interfere with ergosterol biosynthesis and thus alter the structure of the cytoplasmic membrane as well as the function of several membrane-bound enzymes like those involved in nutrient transport and chitin synthesis
D. All of the above
Question 53
The larger the __________ , the better the chemotherapeutic agent.
A. therapeutic index
B. therapeutic dose
C. selective toxicity
D. spectrum
Question 54
Both penicillin and fluoroquinolones
A. bind to and inactivate a bacterial protein
B. inhibit the cross-linking of peptidoglycan
C. are inactivated by β-lactamase
D. must be transported into the cytoplasm in order to act
Question 55
Which of the following is not β-lactamase-resistant penicillin?
A. Oxacillin
B. Nafcillin
C. Carbenicillin
D. Methicillin
Question 56
The susceptibility of a microorganism to antibiotics and other chemotherapeutic agents can be determined by using
A. tube dilution technique
B. paper disk plate
C. Both A and B
D. None of these
Question 57
The nitrofurans differ from the antibiotics in that they
A. do not occur naturally
B. occur naturally
C. are antimicrobial drugs
D. All of the above
Question 58
The antibiotics which affords a broad spectrum of antimicrobial coverage against aerobic and anaerobic bacteria, rickettsiae, chlamydiae, and mycoplasmas is
A. gentamicin
B. tetracycline
C. metronidazole
D. vancomycin
Question 59
Fluoroquinolones are antibiotics which inhibit
A. DNA polymerase
B. RNA polymerase
C. DNA gyrase
D. Cross-linking of peptidoglycan