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Antimicrobial Chemotherapeutic Agents MCQ Questions & Answers

Antimicrobial Chemotherapeutic Agents MCQs : This section focuses on the "Antimicrobial Chemotherapeutic Agents". These Multiple Choice Questions (MCQs) should be practiced to improve the Antimicrobial Chemotherapeutic Agents skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

Which of the following may cause resistance to penicillin?

A. Impermeability of cell envelope
B. Production of β-lactamases by bacteria
C. Alteration or lack of penicillin-binding proteins
D. All of the above

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Question 2

Which antibiotic has a beta-lactam ring?

A. Cephalosporin
B. Penicillin
C. Tetracycline
D. Streptomycin

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Question 3

A parenteral route of drug administration refers to

A. oral
B. nonoral
C. intravenously
D. intramuscularly

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Question 4

Which of the following antibiotics can't be used for treatment of infections with β-lactamase-producing Staphylococcus aureus?

A. Vancomycin
B. Ampicillin/sulbactam
C. Cephalothin
D. Piperacillin

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Question 5

Nystatin is a drug used for treatment of diseases caused by

A. gram negative bacterium
B. gram positive bacterium
C. yeast
D. protozoan

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Question 6

The penicillin resistant to β-lactamases is

A. carbenicillin
B. closacillin
C. penicillin-G
D. ampicillin

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Question 7

A broad-spectrum antibiotic such as chloramphenicol is one that

A. kills both Gram positive and Gram negative bacteria
B. kills all bacteria
C. kills numerous types of microbes
D. kills all microorganisms

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Question 8

Which is not an amino acid and peptide antibiotic?

A. Penicillin
B. Actinomycin
C. Bacitracin
D. Tetranactin

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Question 9

Chelate forming peptide antibiotic are/is

A. bleomycins
B. sideromycins
C. both (a) and (b)
D. vancomycin

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Question 10

Which of the following is not an example of potent antitumer agents?

A. Anthramycin
B. Sibromycin
C. Neothramycin
D. Erythromycin

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Question 11

Amphotericin B and polymyxin interfere with

A. cell wall synthesis
B. protein synthesis
C. cell membrane function
D. DNA function

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Question 12

Which of the following group is not the carbohydrate containing antibiotic?

A. Streptomycin & Streptothricin
B. Vancomycin & Moenomycin
C. Everninomycin & Nogirimycin
D. Erythromycin & candicidin

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Question 13

Which of the following is a drug that interferes with the process of DNA production in the virus that causes genital herpes?

A. Erythromycin
B. Vancomycin
C. Amantadine
D. Acyclovir

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Question 14

Cycloserine inhibits

A. alanine racemase
B. D-alanyl - D-alanine synthetase
C. Both A and B
D. amidase

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Question 15

The susceptibility of a microorganism to antibiotics and other chemotherapeutic agents can be determined by using

A. tube dilution technique
B. paper disk plate
C. both (a) and (b)
D. none of these

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Question 16

Which of the following drugs involves modification of the drug by enzymatic modification or degradation of its active element to alter its/their resistance?

A. Pencillins
B. Choloramphenicol
C. Aminoglyosides
D. All of the above

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Question 17

Who developed the concept of specific toxicity?

A. Pasteur
B. Fleming
C. Watson
D. Ehrlich

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Question 18

The third generation cephalosporin agents is

A. cefotaxime
B. cefoxitin
C. cephalothin
D. cephalexin

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Question 19

The scientist who first discovered the substance penicillin was

A. Joseph Lister
B. Alexander Fleming
C. Paul Ehrlich
D. none of these

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Question 20

Quinolones are

A. antimetabolites
B. penicillin derivatives
C. bacteriostatic
D. broad-spectrum

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Question 21

Which of the following methods would be most appropriate for sterilizing an antibiotic solution?

A. Dry heat sterilization
B. Microfiltration
C. Autoclaving
D. Desiccation

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Question 22

Polyene antibiotics are

A. large ring structures
B. β-lactam - thiazolidine ring
C. small ring structures
D. any of these

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Question 23

Which of the following tests is used to determine the minimal lethal concentration?

A. Broth dilution test
B. Agar dilution test
C. Dilution susceptibility tests
D. All of these

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Question 24

Cycloserine inhibits

A. alanine racemase
B. D-alanyl - D-alanine synthetase
C. Both (a) and (b)
D. amidase

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Question 25

The most selective antibiotics are those that interfere with the synthesis of

A. bacterial DNA
B. bacterial RNA
C. bacterial cell walls
D. bacterial plasma membrane

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Question 26

Which of the following is not a semi synthetic chemotherapeutic agent?

A. Ampicillin
B. Carbenicillin
C. Penicillin
D. Sulfonamide

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Question 27

Novobiocin can be used against

A. gram +ve Staphylococci
B. gram -ve Meningococci & Gonococci
C. Haemophilus
D. All of the above

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Question 28

Which of the following is not an aminoglycoside antibiotic?

A. Streptomycin
B. Neomycin
C. Kanamycin
D. Cephalosporin

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Question 29

Which of the following drugs involves modification of the drug by enzymatic modification or degradation of its active element to alter its/their resistance?

A. Pencillins
B. Choloramphenicol
C. Aminoglyosides
D. All of these

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Question 30

Novobiocin can be used against

A. gram +ve Staphylococci
B. gram -ve Meningococci & Gonococci
C. Haemophilus
D. all of these

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Question 31

Bacterial cells susceptible to penicillium can be protected from destruction if the medium in which they are exposed is of

A. high osmotic pressure
B. low osmotic pressure
C. moderate osmotic pressure
D. high surface tension

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Question 32

Chemotherapeutic agents must

A. prevent/destroy the activity of a parasite
B. leave unaltered the host's natural defense mechanisms
C. be able to come in contact with the parasite by penetrating the cells
D. All of the above

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Question 33

Cephalosporins and Penicillins interfere with which of the following?

A. Protein synthesis
B. DNA function
C. Cell membrane function
D. Cell wall synthesis

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Question 34

The compound(s) which act(s) as metabolic antagonist is/are

A. trimethoprim
B. sulphonamides
C. both (a) and (b)
D. none of these

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Question 35

Which of the following is used only in life-threatening situations when no other drug is adequate?

A. Penicillin
B. Tetracycline
C. Chloramphenicol
D. Streptomycin

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Question 36

The antibiotics not clinically useful for Pseudomonas aeruginosa infection is

A. aminoglycosides
B. ceftazidime
C. piperacillin
D. trimethoprim-sulphamethoxazole

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Question 37

Which of the antibiotic is not used as a food preservative ?

A. Pimaricin
B. Nisin
C. Tylosin
D. β-lactam antibiotic

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Question 38

Interference mechanism of ciprofloxacin and norfloxacin is due to their action on

A. cell wall synthesis
B. cell membrane function
C. DNA function
D. protein synthesis

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Question 39

The mode of action of polymyxin is to

A. inhibit protein synthesis
B. inhibit DNA synthesis
C. injury to the plasma membrane
D. inhibit folic acid synthesis

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Question 40

Which of the following protein synthesis mechanisms may be affected by particular drugs?

A. Peptide bond formation
B. mRNA translocation
C. Aminoacyl-tRNA binding
D. All of these

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Question 41

Quinones and related antibiotics are

A. tetracyclines
B. actinorhodin
C. mitomycin
D. all of these

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Question 42

More promising chemotherapeutic agents for treating viral diseases is

A. leukocytic interferon
B. fibroblast interferon
C. interferon
D. nystatin

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Question 43

The antibiotics not having good activity against Enterobacteriaceae is

A. clindamycin
B. cefoxitin
C. trimethoprim-sulphamethoxazole
D. ciprofloxacin

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Question 44

With which of the following aminoglycosides interfere?

A. Protein synthesis
B. DNA function
C. Cell wall synthesis
D. Cell membrane function

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Question 45

Which of the following drugs may show plasmid-mediated resistance?

A. Nalidixic acid
B. Ampicillin
C. Rifampicin
D. Methicillin

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Question 46

The penicillin stable in gastric acid and suitable for oral administration is

A. methicillin
B. carbenicillin
C. closacillin
D. pencillin-G

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Question 47

Most antibiotics are isolated from

A. viruses
B. aquatic microorganisms
C. soil microorganisms
D. plants

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Question 48

When using alcohol as an antiseptic, which concentration is considered most effective?

A. 95%
B. 50%
C. 70%
D. 25%

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Question 49

By which of the following means antifungal chemotherapeutic agents may affect fungi?

A. Interfere with nuclear division by preventing the aggregation of microtubules needed for mitosis
B. Interfere with normal nucleic acid synthesis
C. Interfere with ergosterol biosynthesis and thus alter the structure of the cytoplasmic membrane as well as the function of several membrane-bound enzymes like those involved in nutrient transport and chitin synthesis
D. all of these

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Question 50

Vancomycin inhibits peptidoglycan synthesis by binding

A. D-alanyl - D-alanine
B. alanine racemase
C. D-alanyl - D-alanine synthetase
D. amidase

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Question 51

The nitrofurans differ from the antibiotics in that they

A. do not occur naturally
B. occur naturally
C. are antimicrobial drugs
D. all of these

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Question 52

By which of the following means antifungal chemotherapeutic agents may affect fungi?

A. Interfere with nuclear division by preventing the aggregation of microtubules needed for mitosis
B. Interfere with normal nucleic acid synthesis
C. Interfere with ergosterol biosynthesis and thus alter the structure of the cytoplasmic membrane as well as the function of several membrane-bound enzymes like those involved in nutrient transport and chitin synthesis
D. All of the above

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Question 53

The larger the __________ , the better the chemotherapeutic agent.

A. therapeutic index
B. therapeutic dose
C. selective toxicity
D. spectrum

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Question 54

Both penicillin and fluoroquinolones

A. bind to and inactivate a bacterial protein
B. inhibit the cross-linking of peptidoglycan
C. are inactivated by β-lactamase
D. must be transported into the cytoplasm in order to act

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Question 55

Which of the following is not β-lactamase-resistant penicillin?

A. Oxacillin
B. Nafcillin
C. Carbenicillin
D. Methicillin

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Question 56

The susceptibility of a microorganism to antibiotics and other chemotherapeutic agents can be determined by using

A. tube dilution technique
B. paper disk plate
C. Both A and B
D. None of these

View Answer

Question 57

The nitrofurans differ from the antibiotics in that they

A. do not occur naturally
B. occur naturally
C. are antimicrobial drugs
D. All of the above

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Question 58

The antibiotics which affords a broad spectrum of antimicrobial coverage against aerobic and anaerobic bacteria, rickettsiae, chlamydiae, and mycoplasmas is

A. gentamicin
B. tetracycline
C. metronidazole
D. vancomycin

View Answer

Question 59

Fluoroquinolones are antibiotics which inhibit

A. DNA polymerase
B. RNA polymerase
C. DNA gyrase
D. Cross-linking of peptidoglycan

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