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Antimicrobial Chemotherapeutic Agents MCQ Questions & Answers

Antimicrobial Chemotherapeutic Agents MCQs : This section focuses on the "Antimicrobial Chemotherapeutic Agents". These Multiple Choice Questions (MCQs) should be practiced to improve the Antimicrobial Chemotherapeutic Agents skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

Which of the following is a drug that interferes with the process of DNA production in the virus that causes genital herpes?

A. Erythromycin
B. Vancomycin
C. Amantadine
D. Acyclovir

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Question 2

Which of the antibiotic is not used as a food preservative ?

A. Pimaricin
B. Nisin
C. Tylosin
D. β-lactam antibiotic

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Question 3

The most selective antibiotics are those that interfere with the synthesis of

A. bacterial DNA
B. bacterial RNA
C. bacterial cell walls
D. bacterial plasma membrane

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Question 4

Cycloserine inhibits

A. alanine racemase
B. D-alanyl - D-alanine synthetase
C. Both A and B
D. amidase

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Question 5

Which antibiotic has a beta-lactam ring?

A. Cephalosporin
B. Penicillin
C. Tetracycline
D. Streptomycin

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Question 6

Chemotherapeutic agents must

A. prevent/destroy the activity of a parasite
B. leave unaltered the host's natural defense mechanisms
C. be able to come in contact with the parasite by penetrating the cells
D. All of the above

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Question 7

Novobiocin can be used against

A. gram +ve Staphylococci
B. gram -ve Meningococci & Gonococci
C. Haemophilus
D. All of the above

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Question 8

Interference mechanism of ciprofloxacin and norfloxacin is due to their action on

A. cell wall synthesis
B. cell membrane function
C. DNA function
D. protein synthesis

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Question 9

By which of the following means antifungal chemotherapeutic agents may affect fungi?

A. Interfere with nuclear division by preventing the aggregation of microtubules needed for mitosis
B. Interfere with normal nucleic acid synthesis
C. Interfere with ergosterol biosynthesis and thus alter the structure of the cytoplasmic membrane as well as the function of several membrane-bound enzymes like those involved in nutrient transport and chitin synthesis
D. All of the above

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Question 10

Which of the following methods would be most appropriate for sterilizing an antibiotic solution?

A. Dry heat sterilization
B. Microfiltration
C. Autoclaving
D. Desiccation

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Question 11

Which of the following drugs involves modification of the drug by enzymatic modification or degradation of its active element to alter its/their resistance?

A. Pencillins
B. Choloramphenicol
C. Aminoglyosides
D. All of the above

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Question 12

Who developed the concept of specific toxicity?

A. Pasteur
B. Fleming
C. Watson
D. Ehrlich

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Question 13

When using alcohol as an antiseptic, which concentration is considered most effective?

A. 95%
B. 50%
C. 70%
D. 25%

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Question 14

Fluoroquinolones are antibiotics which inhibit

A. DNA polymerase
B. RNA polymerase
C. DNA gyrase
D. Cross-linking of peptidoglycan

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Question 15

Which of the following is used only in life-threatening situations when no other drug is adequate?

A. Penicillin
B. Tetracycline
C. Chloramphenicol
D. Streptomycin

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Question 16

The susceptibility of a microorganism to antibiotics and other chemotherapeutic agents can be determined by using

A. tube dilution technique
B. paper disk plate
C. Both A and B
D. None of these

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Question 17

Most antibiotics are isolated from

A. viruses
B. aquatic microorganisms
C. soil microorganisms
D. plants

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Question 18

Which of the following group is not the carbohydrate containing antibiotic?

A. Streptomycin & Streptothricin
B. Vancomycin & Moenomycin
C. Everninomycin & Nogirimycin
D. Erythromycin & candicidin

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Question 19

The penicillin stable in gastric acid and suitable for oral administration is

A. methicillin
B. carbenicillin
C. closacillin
D. pencillin-G

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Question 20

Which of the following is not an example of potent antitumer agents?

A. Anthramycin
B. Sibromycin
C. Neothramycin
D. Erythromycin

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Question 21

More promising chemotherapeutic agents for treating viral diseases is

A. leukocytic interferon
B. fibroblast interferon
C. interferon
D. nystatin

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Question 22

A parenteral route of drug administration refers to

A. oral
B. nonoral
C. intravenously
D. intramuscularly

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Question 23

Which of the following antibiotics can't be used for treatment of infections with β-lactamase-producing Staphylococcus aureus?

A. Vancomycin
B. Ampicillin/sulbactam
C. Cephalothin
D. Piperacillin

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Question 24

Which of the following is not an aminoglycoside antibiotic?

A. Streptomycin
B. Neomycin
C. Kanamycin
D. Cephalosporin

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Question 25

The nitrofurans differ from the antibiotics in that they

A. do not occur naturally
B. occur naturally
C. are antimicrobial drugs
D. All of the above

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Question 26

A broad-spectrum antibiotic such as chloramphenicol is one that

A. kills both Gram positive and Gram negative bacteria
B. kills all bacteria
C. kills numerous types of microbes
D. kills all microorganisms

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Question 27

Amphotericin B and polymyxin interfere with

A. cell wall synthesis
B. protein synthesis
C. cell membrane function
D. DNA function

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Question 28

Bacterial cells susceptible to penicillium can be protected from destruction if the medium in which they are exposed is of

A. high osmotic pressure
B. low osmotic pressure
C. moderate osmotic pressure
D. high surface tension

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Question 29

Both penicillin and fluoroquinolones

A. bind to and inactivate a bacterial protein
B. inhibit the cross-linking of peptidoglycan
C. are inactivated by β-lactamase
D. must be transported into the cytoplasm in order to act

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Question 30

By which of the following means antifungal chemotherapeutic agents may affect fungi?

A. Interfere with nuclear division by preventing the aggregation of microtubules needed for mitosis
B. Interfere with normal nucleic acid synthesis
C. Interfere with ergosterol biosynthesis and thus alter the structure of the cytoplasmic membrane as well as the function of several membrane-bound enzymes like those involved in nutrient transport and chitin synthesis
D. all of these

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Question 31

Cephalosporins and Penicillins interfere with which of the following?

A. Protein synthesis
B. DNA function
C. Cell membrane function
D. Cell wall synthesis

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Question 32

Chelate forming peptide antibiotic are/is

A. bleomycins
B. sideromycins
C. both (a) and (b)
D. vancomycin

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Question 33

Cycloserine inhibits

A. alanine racemase
B. D-alanyl - D-alanine synthetase
C. Both (a) and (b)
D. amidase

View Answer

Question 34

Novobiocin can be used against

A. gram +ve Staphylococci
B. gram -ve Meningococci & Gonococci
C. Haemophilus
D. all of these

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Question 35

Nystatin is a drug used for treatment of diseases caused by

A. gram negative bacterium
B. gram positive bacterium
C. yeast
D. protozoan

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Question 36

Polyene antibiotics are

A. large ring structures
B. β-lactam - thiazolidine ring
C. small ring structures
D. any of these

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Question 37

Quinolones are

A. antimetabolites
B. penicillin derivatives
C. bacteriostatic
D. broad-spectrum

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Question 38

Quinones and related antibiotics are

A. tetracyclines
B. actinorhodin
C. mitomycin
D. all of these

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Question 39

The antibiotics not clinically useful for Pseudomonas aeruginosa infection is

A. aminoglycosides
B. ceftazidime
C. piperacillin
D. trimethoprim-sulphamethoxazole

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Question 40

The antibiotics not having good activity against Enterobacteriaceae is

A. clindamycin
B. cefoxitin
C. trimethoprim-sulphamethoxazole
D. ciprofloxacin

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Question 41

The antibiotics which affords a broad spectrum of antimicrobial coverage against aerobic and anaerobic bacteria, rickettsiae, chlamydiae, and mycoplasmas is

A. gentamicin
B. tetracycline
C. metronidazole
D. vancomycin

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Question 42

The compound(s) which act(s) as metabolic antagonist is/are

A. trimethoprim
B. sulphonamides
C. both (a) and (b)
D. none of these

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Question 43

The larger the __________ , the better the chemotherapeutic agent.

A. therapeutic index
B. therapeutic dose
C. selective toxicity
D. spectrum

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Question 44

The mode of action of polymyxin is to

A. inhibit protein synthesis
B. inhibit DNA synthesis
C. injury to the plasma membrane
D. inhibit folic acid synthesis

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Question 45

The nitrofurans differ from the antibiotics in that they

A. do not occur naturally
B. occur naturally
C. are antimicrobial drugs
D. all of these

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Question 46

The penicillin resistant to β-lactamases is

A. carbenicillin
B. closacillin
C. penicillin-G
D. ampicillin

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Question 47

The scientist who first discovered the substance penicillin was

A. Joseph Lister
B. Alexander Fleming
C. Paul Ehrlich
D. none of these

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Question 48

The susceptibility of a microorganism to antibiotics and other chemotherapeutic agents can be determined by using

A. tube dilution technique
B. paper disk plate
C. both (a) and (b)
D. none of these

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Question 49

The third generation cephalosporin agents is

A. cefotaxime
B. cefoxitin
C. cephalothin
D. cephalexin

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Question 50

Vancomycin inhibits peptidoglycan synthesis by binding

A. D-alanyl - D-alanine
B. alanine racemase
C. D-alanyl - D-alanine synthetase
D. amidase

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Question 51

Which is not an amino acid and peptide antibiotic?

A. Penicillin
B. Actinomycin
C. Bacitracin
D. Tetranactin

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Question 52

Which of the following drugs involves modification of the drug by enzymatic modification or degradation of its active element to alter its/their resistance?

A. Pencillins
B. Choloramphenicol
C. Aminoglyosides
D. All of these

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Question 53

Which of the following drugs may show plasmid-mediated resistance?

A. Nalidixic acid
B. Ampicillin
C. Rifampicin
D. Methicillin

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Question 54

Which of the following is not a semi synthetic chemotherapeutic agent?

A. Ampicillin
B. Carbenicillin
C. Penicillin
D. Sulfonamide

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Question 55

Which of the following is not β-lactamase-resistant penicillin?

A. Oxacillin
B. Nafcillin
C. Carbenicillin
D. Methicillin

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Question 56

Which of the following may cause resistance to penicillin?

A. Impermeability of cell envelope
B. Production of β-lactamases by bacteria
C. Alteration or lack of penicillin-binding proteins
D. All of the above

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Question 57

Which of the following protein synthesis mechanisms may be affected by particular drugs?

A. Peptide bond formation
B. mRNA translocation
C. Aminoacyl-tRNA binding
D. All of these

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Question 58

Which of the following tests is used to determine the minimal lethal concentration?

A. Broth dilution test
B. Agar dilution test
C. Dilution susceptibility tests
D. All of these

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Question 59

With which of the following aminoglycosides interfere?

A. Protein synthesis
B. DNA function
C. Cell wall synthesis
D. Cell membrane function

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