Cell Cycle MCQs : This section focuses on the "Cell Cycle". These Multiple Choice Questions (MCQs) should be practiced to improve the Cell Cycle skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.
Question 1
Which of the following from a blood clot stimulates the growth of cells in the healing process?
A. EGF
B. PDGF
C. MPF
D. NGF
Question 2
The spindle forms in the
A. G1 phase
B. G2 phase
C. M phase
D. S phase
Question 3
Which phase of mitosis is associated with chromosomes aligned at the center of the cell and centromeres divide?
A. anaphase
B. interphase
C. metaphase
D. prophase
Question 4
The event(s) which does not occur during interphase, is/are
A. Chromatin condenses
B. Protein Synthesis
C. Organelles replication
D. DNA replication
Question 5
In prokaryotes, just before the cell divides, the two daughter genomes are attached side by side to the
A. cell membrane
B. replication origin
C. centromeres
D. equatorial plate
Question 6
In the cell cycle replication of the genome occurs in the
A. G1 phase
B. G2 phase
C. M phase
D. S phase
Question 7
At which of the following check point, mitosis is controlled?
A. G1
B. G2
C. M
D. S
Question 8
The centromeres move toward the poles in __________ .
A. anaphase
B. interphase
C. metaphase
D. prophase
Question 9
Which phase of mitosis is associated with separation of chromatids?
A. Prophase
B. Metaphase
C. Anaphase
D. Telophase
Question 10
Sequences that correctly describes the cell cycle is
A. -> G1-> G2 -> S -> mitosis -> cytokinesis ->
B. -> S -> G2 -> mitosis -> cytokinesis -> G1 ->
C. -> G1 ->S -> G2 -> cytokinesis -> mitosis ->
D. ->cytokinesis-> mitosis -> G1 -> S -> G2 ->
Question 11
Which of the following triggers the division of activated T lymphocytes?
A. FGF
B. Interlukin 2
C. PDGF
D. Erythroprotein
Question 12
The term, not related to mitosis is
A. gametes
B. chromosomes
C. DNA replication
D. somatic cells
Question 13
What structure forms as a network of protein cables during cell division?
A. Spindle
B. Aster
C. Kinetochore
D. Chromatid
Question 14
A centromere is
A. another name for kinetochore
B. the structure to which microtubules attach
C. a constriction on a chromosome bound to a disk
D. All of the above
Question 15
Which of the following statements about mitosis is incorrect?
A. The daughter nuclei are genetically identical to the parent nucleus
B. Chromosomes separate during anaphase due to the interaction of polar microtubules from opposite poles pushing against each other
C. Chromosomes separate during anaphase when the kinetochore microtubules shorten as they depolymerize
D. Chromosomes move to the metaphase plate using motor proteins, a kind of kinesin, attached to spindle fibers
Question 16
Cdks bind with __________ , enabling the Cdks to function as enzymes.
A. MPF
B. cyclins
C. histones
D. p^53
Question 17
Which of the following is not a part of a human chromosome in any phase?
A. Centriole
B. Histone
C. Nucleosome
D. Centromere
Question 18
During which phase, a cleavage furrow is formed in animal cells?
A. C
B. G1
C. G2
D. M
Question 19
In which phase, each chromosome replicates to produce two sister chromatids?
A. Anaphase
B. Interphase
C. Metaphase
D. Prophase
Question 20
Microtubules grow from the poles to kinetochores of each chromatid during
A. prophase
B. metaphase
C. anaphase
D. telophase
Question 21
A nuclear envelope forms around each set of sister chromatids in
A. anaphase
B. metaphase
C. prophase
D. telophase
Question 22
At the __________ checkpoint, cell growth is controlled.
A. C
B. G1
C. G2
D. S
Question 23
At the center of the cell cycle control system is Cdk, a protein that
A. is phosphorylated to become active
B. binds to different cyclins
C. is only active during mitosis
D. manufactures growth factors
Question 24
Cdks bind with __________ , enabling the Cdks to function as enzymes.
A. MPF
B. cyclins
C. histones
D. p53
Question 25
Cells which no longer divide (such as certain specialized cells found in the human brain) remain in which phase of the cell cycle?
A. Prophase
B. S phase
C. G0 Phase
D. Gl Phase
Question 26
DNA replication is controlled at which of the following checkpoint?
A. G1
B. G2
C. M
D. S
Question 27
Each chromosome contains two chromatids by the end of the __________ phase in the life cycle of a human cell.
A. C
B. G2
C. M
D. S
Question 28
How many chromatids are there in a duplicated chromosome?
A. One
B. Two
C. Three
D. Four
Question 29
How many chromatids does a diploid body cell contain just prior to cell division?
A. 23
B. 46
C. 69
D. 92
Question 30
In which of the following phase preparations for genome separation are made?
A. C
B. G1
C. G2
D. M
Question 31
The cell cycle is controlled in most cells by
A. time (after a certain length of time the cell divides)
B. a series of checkpoints
C. cell size (when the cell reaches a certain size, it divides)
D. different cells exhibit different control strategies
Question 32
The G0 phase is
A. a permanent state of all body cells
B. the state of most cells in an animal body
C. another name for interphase
D. all of the above
Question 33
The phase of mitosis which is associated with the formation of the nuclear envelope, is
A. prophase
B. metaphase
C. anaphase
D. telophase
Question 34
The term homologous chromosomes
A. refers to replications of the same chromosome
B. is another name for sister chromatids
C. must be haploid
D. means a pair of chromosomes of the same kind, such as sex chromosomes
Question 35
Which of the following begins when pairs of sister chromatids align in the center of the cell?
A. Anaphase
B. Interphase
C. Metaphase
D. Prophase
Question 36
Which of the following is the normal cell cycle, primarily regulated at checkpoints?
A. Metaphase in mitosis
B. Anaphase, G1 boundary
C. G1-S boundary
D. S-G2 boundary
Question 37
Which of the following is the primary growth phase of a cell?
A. G1
B. G2
C. M
D. G0
Question 38
DNA synthesis involves an increase in chromosome number. True or false?
A. True
B. False
Question 39
During S phase of the cell cycle, the amount of DNA ______
A. triples
B. remains the same
C. quadruples
D. doubles
Question 40
How much time of the entire cell cycle is occupied by interphase?
A. 75%
B. 95%
C. 50%
D. 80%
Question 41
In which of these animals does a haploid cell divide mitotically?
A. Humans
B. Male honey bees
C. Female honey bees
D. Rats
Question 42
In which phase of the cell cycle does centriole duplication take place?
A. S phase
B. G2 phase
C. G1 phase
D. G0 phase
Question 43
In which phase of the cell cycle does DNA replication take place?
A. Anaphase
B. Metaphase
C. Prophase
D. Interphase
Question 44
Protein synthesis takes place in _____
A. G0 phase
B. G1 phase
C. G2 phase
D. S phase
Question 45
The period between two M phases is called ______
A. interphase
B. prophase
C. prometaphase
D. telophase
Question 46
What is the duration of cell cycle in yeast?
A. 30 minutes
B. 24 hours
C. 90 minutes
D. 48 hours
Question 47
What is the interval between mitosis and DNA replication?
A. S phase
B. G2 phase
C. G1 phase
D. M phase
Question 48
Which of these cells do not divide?
A. Heart cells
B. Melanocytes
C. Osteocytes
D. Liver cells
Question 49
Which of these is the correct order of events in the cell cycle?
A. G1 → G2 → S → M
B. G1 → G2 → M → S
C. G1 → S → G2 → M
D. S → M → G1 → G2
Question 50
Which of these processes is not a part of the cell cycle?
A. Duplication of genome
B. Division into daughter cells
C. Synthesis of cell organelles
D. Degeneration of centrosome
Question 51
Which process does the M phase of cell cycle start with?
A. Karyokinesis
B. Cytokinesis
C. Interphase
D. Spindle formation
Question 52
Asynchronous cultures are the ones whose cells are _______________________
A. of different origin
B. randomly distributed through the cell cycle
C. have different genomic content
D. have different nutrient requirements
Question 53
Cells that have stopped dividing and are arrested in a state preceding that of DNA synthesis, are said to be in the__________
A. S phase
B. G1 phase
C. G0 phase
D. G2 phase
Question 54
Cyclin binding leads to a change in the _________________ of kinase.
A. pH
B. temperature
C. concentration
D. conformation
Question 55
DNA replication can be monitored by incorporation of ______________________
A. tyrosine
B. thymidine
C. cytosine
D. nitite
Question 56
DNA replication occurs during _________________ of the cell cycle.
A. S phase
B. Interphase
C. G2 phase
D. G0 phase
Question 57
Meiosis produces cells that have half the genetic content as their parent cells.
A. True
B. False
Question 58
The entry of a cell into M phase is initiated by _________________
A. interleukin factor
B. maturation promoting factor
C. transcription factor
D. necrosis factor
Question 59
The regulatory subunit of maturation-promoting factor (MPF) is called _______________
A. kinase
B. cyclin
C. tetracyclin
D. interleukin
Question 60
There are ______ major phases in a cell cycle.
A. 1
B. 2
C. 3
D. 4
Question 61
What will happen if a G2 phase cell is fused with an M phase cell?
A. premature chromosome compaction
B. chromosome aggregation
C. gene transcription
D. inhibition of transcription
Question 62
When were the experiments in an effort to understand cell cycle regulation first conducted?
A. 1970s
B. 1980s
C. 1990s
D. 2000s
Question 63
Which of the following cells are capable of asymmetric cell division?
A. Hepatocytes
B. Epithelial cells
C. Stem cells
D. Neurons
Question 64
Which of the following cells do not lack the ability to divide?
A. skin cells
B. nerve cells
C. muscle cells
D. red blood cells
Question 65
Which of the following cells do not usually divide but can be induced to divide?
A. red blood cells
B. liver cells
C. hair cells
D. hair follicles
Question 66
Which term is used to refer to a period between the cell divisions?
A. M phase
B. G0 phase
C. Interphase
D. Resting phase
Question 67
Cyclin dependent kinases are activated by which of the following?
A. Binding to cyclin
B. Binding to cyclin and CDK activating protein kinases
C. Phosphorylation with CDK activating kinase
D. Phosphorylation with tyrosine kinase
Question 68
How many hours does the M phase take to complete a cycle?
A. 8hr
B. 1 hr
C. 4 hr
D. 11 hr
Question 69
Name the cyclin which takes part in M phase?
A. Cyclin E
B. Cyclin A
C. Cyclin D
D. Cyclin B
Question 70
Name the enzyme which causes ubiquitylation and destruction of cyclin.
A. Acid hydrolases
B. Hyaluronidase
C. Ubiquitin ligase
D. Phosphatase
Question 71
Name the regulatory component of the cell cycle?
A. Cyclin
B. CDK
C. DNA
D. APC
Question 72
Name the state where never dividing cells of neurons and skeletal muscle present?
A. G0
B. G1
C. G2
D. M
Question 73
Name the process of nuclear division?
A. Ubiquitylation
B. Polymerization
C. Karyokinesis
D. Cytokinesis
Question 74
Resting phase of the cell, where it undergoes growth and DNA replication is called_________
A. Mitosis phase
B. G1 phase
C. Interphase
D. M phase
Question 75
Replication of DNA takes place in S phase.
A. True
B. False
Question 76
Which of the following is not the part of Interphase in the cell cycle?
A. S phase
B. G1 phase
C. G2 phase
D. M phase