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Cell Cycle MCQ Questions & Answers

Cell Cycle MCQs : This section focuses on the "Cell Cycle". These Multiple Choice Questions (MCQs) should be practiced to improve the Cell Cycle skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

Which of the following from a blood clot stimulates the growth of cells in the healing process?

A. EGF
B. PDGF
C. MPF
D. NGF

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Question 2

The spindle forms in the

A. G1 phase
B. G2 phase
C. M phase
D. S phase

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Question 3

Which phase of mitosis is associated with chromosomes aligned at the center of the cell and centromeres divide?

A. anaphase
B. interphase
C. metaphase
D. prophase

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Question 4

The event(s) which does not occur during interphase, is/are

A. Chromatin condenses
B. Protein Synthesis
C. Organelles replication
D. DNA replication

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Question 5

In prokaryotes, just before the cell divides, the two daughter genomes are attached side by side to the

A. cell membrane
B. replication origin
C. centromeres
D. equatorial plate

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Question 6

In the cell cycle replication of the genome occurs in the

A. G1 phase
B. G2 phase
C. M phase
D. S phase

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Question 7

At which of the following check point, mitosis is controlled?

A. G1
B. G2
C. M
D. S

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Question 8

The centromeres move toward the poles in __________ .

A. anaphase
B. interphase
C. metaphase
D. prophase

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Question 9

Which phase of mitosis is associated with separation of chromatids?

A. Prophase
B. Metaphase
C. Anaphase
D. Telophase

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Question 10

Sequences that correctly describes the cell cycle is

A. -> G1-> G2 -> S -> mitosis -> cytokinesis ->
B. -> S -> G2 -> mitosis -> cytokinesis -> G1 ->
C. -> G1 ->S -> G2 -> cytokinesis -> mitosis ->
D. ->cytokinesis-> mitosis -> G1 -> S -> G2 ->

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Question 11

Which of the following triggers the division of activated T lymphocytes?

A. FGF
B. Interlukin 2
C. PDGF
D. Erythroprotein

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Question 12

The term, not related to mitosis is

A. gametes
B. chromosomes
C. DNA replication
D. somatic cells

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Question 13

What structure forms as a network of protein cables during cell division?

A. Spindle
B. Aster
C. Kinetochore
D. Chromatid

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Question 14

A centromere is

A. another name for kinetochore
B. the structure to which microtubules attach
C. a constriction on a chromosome bound to a disk
D. All of the above

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Question 15

Which of the following statements about mitosis is incorrect?

A. The daughter nuclei are genetically identical to the parent nucleus
B. Chromosomes separate during anaphase due to the interaction of polar microtubules from opposite poles pushing against each other
C. Chromosomes separate during anaphase when the kinetochore microtubules shorten as they depolymerize
D. Chromosomes move to the metaphase plate using motor proteins, a kind of kinesin, attached to spindle fibers

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Question 16

Cdks bind with __________ , enabling the Cdks to function as enzymes.

A. MPF
B. cyclins
C. histones
D. p^53

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Question 17

Which of the following is not a part of a human chromosome in any phase?

A. Centriole
B. Histone
C. Nucleosome
D. Centromere

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Question 18

During which phase, a cleavage furrow is formed in animal cells?

A. C
B. G1
C. G2
D. M

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Question 19

In which phase, each chromosome replicates to produce two sister chromatids?

A. Anaphase
B. Interphase
C. Metaphase
D. Prophase

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Question 20

Microtubules grow from the poles to kinetochores of each chromatid during

A. prophase
B. metaphase
C. anaphase
D. telophase

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Question 21

A nuclear envelope forms around each set of sister chromatids in

A. anaphase
B. metaphase
C. prophase
D. telophase

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Question 22

At the __________ checkpoint, cell growth is controlled.

A. C
B. G1
C. G2
D. S

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Question 23

At the center of the cell cycle control system is Cdk, a protein that

A. is phosphorylated to become active
B. binds to different cyclins
C. is only active during mitosis
D. manufactures growth factors

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Question 24

Cdks bind with __________ , enabling the Cdks to function as enzymes.

A. MPF
B. cyclins
C. histones
D. p53

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Question 25

Cells which no longer divide (such as certain specialized cells found in the human brain) remain in which phase of the cell cycle?

A. Prophase
B. S phase
C. G0 Phase
D. Gl Phase

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Question 26

DNA replication is controlled at which of the following checkpoint?

A. G1
B. G2
C. M
D. S

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Question 27

Each chromosome contains two chromatids by the end of the __________ phase in the life cycle of a human cell.

A. C
B. G2
C. M
D. S

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Question 28

How many chromatids are there in a duplicated chromosome?

A. One
B. Two
C. Three
D. Four

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Question 29

How many chromatids does a diploid body cell contain just prior to cell division?

A. 23
B. 46
C. 69
D. 92

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Question 30

In which of the following phase preparations for genome separation are made?

A. C
B. G1
C. G2
D. M

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Question 31

The cell cycle is controlled in most cells by

A. time (after a certain length of time the cell divides)
B. a series of checkpoints
C. cell size (when the cell reaches a certain size, it divides)
D. different cells exhibit different control strategies

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Question 32

The G0 phase is

A. a permanent state of all body cells
B. the state of most cells in an animal body
C. another name for interphase
D. all of the above

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Question 33

The phase of mitosis which is associated with the formation of the nuclear envelope, is

A. prophase
B. metaphase
C. anaphase
D. telophase

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Question 34

The term homologous chromosomes

A. refers to replications of the same chromosome
B. is another name for sister chromatids
C. must be haploid
D. means a pair of chromosomes of the same kind, such as sex chromosomes

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Question 35

Which of the following begins when pairs of sister chromatids align in the center of the cell?

A. Anaphase
B. Interphase
C. Metaphase
D. Prophase

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Question 36

Which of the following is the normal cell cycle, primarily regulated at checkpoints?

A. Metaphase in mitosis
B. Anaphase, G1 boundary
C. G1-S boundary
D. S-G2 boundary

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Question 37

Which of the following is the primary growth phase of a cell?

A. G1
B. G2
C. M
D. G0

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Question 38

DNA synthesis involves an increase in chromosome number. True or false?

A. True
B. False

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Question 39

During S phase of the cell cycle, the amount of DNA ______

A. triples
B. remains the same
C. quadruples
D. doubles

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Question 40

How much time of the entire cell cycle is occupied by interphase?

A. 75%
B. 95%
C. 50%
D. 80%

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Question 41

In which of these animals does a haploid cell divide mitotically?

A. Humans
B. Male honey bees
C. Female honey bees
D. Rats

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Question 42

In which phase of the cell cycle does centriole duplication take place?

A. S phase
B. G2 phase
C. G1 phase
D. G0 phase

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Question 43

In which phase of the cell cycle does DNA replication take place?

A. Anaphase
B. Metaphase
C. Prophase
D. Interphase

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Question 44

Protein synthesis takes place in _____

A. G0 phase
B. G1 phase
C. G2 phase
D. S phase

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Question 45

The period between two M phases is called ______

A. interphase
B. prophase
C. prometaphase
D. telophase

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Question 46

What is the duration of cell cycle in yeast?

A. 30 minutes
B. 24 hours
C. 90 minutes
D. 48 hours

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Question 47

What is the interval between mitosis and DNA replication?

A. S phase
B. G2 phase
C. G1 phase
D. M phase

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Question 48

Which of these cells do not divide?

A. Heart cells
B. Melanocytes
C. Osteocytes
D. Liver cells

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Question 49

Which of these is the correct order of events in the cell cycle?

A. G1 → G2 → S → M
B. G1 → G2 → M → S
C. G1 → S → G2 → M
D. S → M → G1 → G2

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Question 50

Which of these processes is not a part of the cell cycle?

A. Duplication of genome
B. Division into daughter cells
C. Synthesis of cell organelles
D. Degeneration of centrosome

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Question 51

Which process does the M phase of cell cycle start with?

A. Karyokinesis
B. Cytokinesis
C. Interphase
D. Spindle formation

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Question 52

Asynchronous cultures are the ones whose cells are _______________________

A. of different origin
B. randomly distributed through the cell cycle
C. have different genomic content
D. have different nutrient requirements

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Question 53

Cells that have stopped dividing and are arrested in a state preceding that of DNA synthesis, are said to be in the__________

A. S phase
B. G1 phase
C. G0 phase
D. G2 phase

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Question 54

Cyclin binding leads to a change in the _________________ of kinase.

A. pH
B. temperature
C. concentration
D. conformation

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Question 55

DNA replication can be monitored by incorporation of ______________________

A. tyrosine
B. thymidine
C. cytosine
D. nitite

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Question 56

DNA replication occurs during _________________ of the cell cycle.

A. S phase
B. Interphase
C. G2 phase
D. G0 phase

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Question 57

Meiosis produces cells that have half the genetic content as their parent cells.

A. True
B. False

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Question 58

The entry of a cell into M phase is initiated by _________________

A. interleukin factor
B. maturation promoting factor
C. transcription factor
D. necrosis factor

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Question 59

The regulatory subunit of maturation-promoting factor (MPF) is called _______________

A. kinase
B. cyclin
C. tetracyclin
D. interleukin

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Question 60

There are ______ major phases in a cell cycle.

A. 1
B. 2
C. 3
D. 4

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Question 61

What will happen if a G2 phase cell is fused with an M phase cell?

A. premature chromosome compaction
B. chromosome aggregation
C. gene transcription
D. inhibition of transcription

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Question 62

When were the experiments in an effort to understand cell cycle regulation first conducted?

A. 1970s
B. 1980s
C. 1990s
D. 2000s

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Question 63

Which of the following cells are capable of asymmetric cell division?

A. Hepatocytes
B. Epithelial cells
C. Stem cells
D. Neurons

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Question 64

Which of the following cells do not lack the ability to divide?

A. skin cells
B. nerve cells
C. muscle cells
D. red blood cells

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Question 65

Which of the following cells do not usually divide but can be induced to divide?

A. red blood cells
B. liver cells
C. hair cells
D. hair follicles

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Question 66

Which term is used to refer to a period between the cell divisions?

A. M phase
B. G0 phase
C. Interphase
D. Resting phase

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Question 67

Cyclin dependent kinases are activated by which of the following?

A. Binding to cyclin
B. Binding to cyclin and CDK activating protein kinases
C. Phosphorylation with CDK activating kinase
D. Phosphorylation with tyrosine kinase

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Question 68

How many hours does the M phase take to complete a cycle?

A. 8hr
B. 1 hr
C. 4 hr
D. 11 hr

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Question 69

Name the cyclin which takes part in M phase?

A. Cyclin E
B. Cyclin A
C. Cyclin D
D. Cyclin B

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Question 70

Name the enzyme which causes ubiquitylation and destruction of cyclin.

A. Acid hydrolases
B. Hyaluronidase
C. Ubiquitin ligase
D. Phosphatase

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Question 71

Name the regulatory component of the cell cycle?

A. Cyclin
B. CDK
C. DNA
D. APC

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Question 72

Name the state where never dividing cells of neurons and skeletal muscle present?

A. G0
B. G1
C. G2
D. M

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Question 73

Name the process of nuclear division?

A. Ubiquitylation
B. Polymerization
C. Karyokinesis
D. Cytokinesis

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Question 74

Resting phase of the cell, where it undergoes growth and DNA replication is called_________

A. Mitosis phase
B. G1 phase
C. Interphase
D. M phase

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Question 75

Replication of DNA takes place in S phase.

A. True
B. False

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Question 76

Which of the following is not the part of Interphase in the cell cycle?

A. S phase
B. G1 phase
C. G2 phase
D. M phase

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