Immune Response MCQs : This section focuses on the "Immune Response". These Multiple Choice Questions (MCQs) should be practiced to improve the Immune Response skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.
Question 1
B and T lymphocytes arise from _____________
A. hematopoietic stem cells
B. germ cells
C. somatic cells
D. spermatocytes
Question 2
Which of the following systems protects our body against disease-causing microbes?
A. Immune system
B. Digestive system
C. Excretory system
D. Respiratory system
Question 3
In cellular immunity, T lymphocytes are responsible for the recognition and killing of foreign invaders. The cells are
A. cytotoxic T lymphocytes (CTL)
B. killer T cells
C. both (a) and (b)
D. none of the above
Question 4
To elicit the best antibodies to mouse MHC I, it should be injected into a
A. goat
B. mouse of the same genetic background (strain)
C. mouse of a different strain
D. rat
Question 5
Which type of immune cells are responsible for eradicating intracellular pathogens?
A. natural killer cells
B. mast cells
C. neurons
D. specific lymphocytes
Question 6
Which of the following group of pathogens always reside intracellularly in the host?
A. virus
B. fungi
C. molds
D. bacteria
Question 7
What is not required in the innate immune responses?
A. antigen
B. strong immunity
C. pathogen
D. previous contact
Question 8
Polysaccharides on the surface of infecting microorganisms can also activate complement directly in the absence of
A. antibody via the alternative pathway
B. antigen via the alternative pathway
C. antibody via metabolic pathway
D. none of the above
Question 9
Which of the following lymphokine(s) is secreted by delayed-type-hypersensitivity cells?
A. Macrophage stimulating factor
B. Migration inhibiting factor
C. Macrophage activating factor
D. All of the above
Question 10
Adaptive immune responses are more specific that innate immune responses.
A. True
B. False
Question 11
Which of the following drug acts by stimulating toll-like receptors (TLRs)?
A. Doxorubicin
B. Neosporin
C. Aldara
D. Vimentin
Question 12
Overactivity of Th cells may result into
A. autoimmunity
B. optimal antibody response
C. optimal cell-mediated response
D. none of the above
Question 13
Negative phase is observed in
A. secondary humoral response
B. primary humoral response
C. Both A and B
D. None of these
Question 14
Lens antigens of the eye are
A. cross-reacting antigens
B. sequestrated antigens
C. neoantigens
D. None of these
Question 15
Induction of tolerance mechanism(s) is/are
A. suppression
B. clonal deletion
C. clonal anergy
D. all of these
Question 16
What is the result of an abnormal response of the immune system to part of a person's own body?
A. Passive immunity
B. Cancer
C. An allergic response
D. An autoimmune disease
Question 17
In which of the following cell mediated immunity (CMI) participates?
A. Delayed hypersensitivity reaction
B. Graft versus host reaction
C. Allograft rejection
D. All of the above
Question 18
Method(s) that can be used to detect CMI is/are
A. migration inhibition
B. target cell destruction factor test
C. skin test for delayed hypersensitivity
D. All of the above
Question 19
If a person is vaccinated against a disease sometime in the past, which of the following is currently in your body?
A. The disease organism itself and antigens for the disease organism
B. A very high level of antibodies against the disease antigens
C. Memory B lymphocytes for the antigen of this disease organism
D. All of the above
Question 20
What are the solutions prepared from weakened or dead microorganisms, viruses, or toxins that provide some immunity from diseases?
A. Vaccines
B. Histamines
C. Drugs
D. Antibiotics
Question 21
Immunosuppressive agent(s) is/are
A. Cyclosporine
B. Methotrexate
C. Anti-lymphocytic serum
D. All of these
Question 22
Plasma cells produce thousands of __________ that are released into the bloodstream
A. antigens
B. antibodies
C. helper T cells
D. virus fragments
Question 23
Which of the following is an antimicrobial peptide synthesized by lymphocytes?
A. adhesins
B. condensins
C. defensins
D. complement
Question 24
A rare disease congenital agammaglobulinemia is caused due to abnormality in __________________
A. humoral antibody
B. cell-mediated immunity
C. acidic/alkaline pH
D. homeostasis
Question 25
Immunosuppressive agent(s) is/are
A. Cyclosporine
B. Methotrexate
C. Anti-lymphocytic serum
D. All of the above
Question 26
Innate immune responses are accompanied by inflammation.
A. True
B. False
Question 27
Induction of tolerance mechanism(s) is/are
A. suppression
B. clonal deletion
C. clonal anergy
D. All of the above
Question 28
Overactivity of Th cells may result into
A. autoimmunity
B. optimal antibody response
C. optimal cell-mediated response
D. None of these
Question 29
Immunogenicity
A. depends on the ability of the native antigen to be presented by MHC
B. is usually a property of self antigens such as eye tissue
C. is not a property of antibodies
D. is not a property of haptens
Question 30
The immune response to a booster vaccine is called a(n)
A. cellular response
B. innate response
C. primary response
D. secondary response
Question 31
Humoral immunity is mediated by ______________
A. mast cells
B. neutrophils
C. lymphocytes
D. leukocytes
Question 32
Immunological memory is due to
A. short lived macrophage that can recognize specific pathogens
B. long lived B cells that secrete a specific antibody
C. long lived B cells that secrete a specific antigen
D. short lived helper T cells that signal macrophage to divide
Question 33
Negative phase is observed in
A. secondary humoral response
B. primary humoral response
C. both (a) and (b)
D. none of the above
Question 34
The phagocytes can recognize pathogens by means of _____________________
A. necrosis factor
B. complement activation
C. pattern recognition receptors
D. adhesion molecules
Question 35
Which of the following is an example of autoimmune disease?
A. Rheumatoid arthritis
B. Systemic lupus erythematosus
C. Polyarteritis nodosa
D. All of the above
Question 36
Which type of interferons is associated with an antiviral innate response?
A. Type I
B. Type II
C. Type III
D. Type IV
Question 37
What is a protein produced by host cells infected by viruses?
A. Interferon
B. Histamine
C. Antiserum
D. Vaccine
Question 38
Which of the following is in the lymph nodes of a person battling a cold virus?
A. Huge numbers of white blood cells
B. Trapped viruses that have been roaming the body
C. Lymph ducts that enter and exit the nodes and Lymph fluid
D. All of the above
Question 39
Which of the following proteins in fruit fly play the major function of dorsoventral polarity of the fly embryo?
A. Toll
B. NEF1
C. Transposons
D. Linker DNA
Question 40
Which of the following immune cells would have an especially low count in a patient with advanced AIDS?
A. Killer T lymphocytes
B. Helper T lymphocyte
C. B lymphocytes
D. None of these
Question 41
Antibodies bound to an invading microorganism activate the complement system via
A. classical pathway
B. metabolic pathway
C. Embden Meyerhof pathway
D. Entner-Doudoroff pathway
Question 42
To detect a humoral immune response to influenza virus, it is possible to measure
A. cytotoxicity of virus-infected cells in tissue culture
B. dividing T cells in the draining lymph nodes
C. plasma cytokine levels
D. serum antibody titer
Question 43
During exposure to a foreign invader, there are more __________ present in the vertebrate body than before exposure
A. antibodies
B. lymphocytes
C. macrophages and antigens
D. all of these