Immune System MCQs : This section focuses on the "Immune System". These Multiple Choice Questions (MCQs) should be practiced to improve the Immune System skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.
Question 1
CD8 surface antigen is present in
A. cytotoxic T cells
B. suppresssor T cells
C. both (a) and (b)
D. none of these
Question 2
Which of the following provide specific defense against viruses and bacteria?
A. T cells
B. B cells
C. Complement
D. inflammation
Question 3
In a fetus, where are lymphocytes produced?
A. In the spleen
B. In the bone marrow
C. In the liver
D. In the heart
Question 4
Which of the following is correct for isoantigens?
A. They are antigens found in all members of different species
B. They are antigens found in some members of a species
C. They are antigens found in all members of a species
D. They are antigens found in some members of different species
Question 5
Following are the defenses of the colon except
A. sIgA
B. fast flow rate
C. dense resident microbiota
D. mucus
Question 6
What is the behavior in which T cells and B cells constantly travel throughout the body seeking out and destroying foreign substances?
A. Antibody-mediated immune response
B. Immune surveillance
C. Cell-mediated immune response
D. Vaccination
Question 7
Which of the following(s) is/are the determinants of antigenicity?
A. Chemical nature
B. Size of the antigen
C. Foreignness
D. All of these
Question 8
Which of the following(s) is/are the determinants of antigenicity?
A. Chemical nature
B. Size of the antigen
C. Foreignness
D. All of the above
Question 9
Which of the following is correct for CD8 T cells?
A. CD8 T cells only recognize virus-infected cells
B. CD8 T cell receptor recognizes epitopes that are also commonly recognized by B cells
C. In the thymus, CD8 T cells undergo positive selection only, whereas CD4 T cells undergo negative selection only
D. CD8 T cells can kill individual virus-infected cells in a contact dependent fashion
Question 10
Lysozyme is present in
A. sweat
B. Cerebro spinal fluid (CSF)
C. urine
D. saliva
Question 11
Which of the following is correct?
A. All T Cells are CD4+
B. An epitope can have multiple antigens
C. T Cell receptors are generated by random assortment of gene cassettes
D. MHC Class II molecules are generated by random assortment of gene cassettes
Question 12
Polymorphonuclear leukocytes (or PMNs)
A. can be attracted to the site of an infection following activation of complement
B. are derived from bone marrow stem cells
C. are a type of phagocyte that can engulf and kill bacteria
D. All of the above
Question 13
The maturation of T cells and the production of particular T cell receptors occurs in the
A. thyroid gland
B. thymus gland
C. testes
D. all of these
Question 14
Which of the following statements is false regarding B cells?
A. B cells can undergo class switching and produce a different antibody type
B. B one marrow stem cells migrate to the thymus and develop into B cells
C. B cells synthesize antibodies and put them on their cell surface
D. B cells that recognize high concentrations of antigens (self) in the absence of other signals undergo apoptosis in the bone marrow
Question 15
Major Histo Compatibility Complex (MHC) is a collection of genes arrayed on
A. chromosome 21 in man, chromosome 6 in mice
B. chromosome 6 in man, chromosone 21 in mice
C. chromosome 17in man, chromosome 6 in mice
D. chromosome 6 in man, chromosome 17 in mice
Question 16
Treatment with bacterial endotoxins results blast formation in
A. B cells
B. T cells
C. monocytes
D. None of these
Question 17
Which of the following is not part of the vertebrate immune system?
A. Lymphocytes
B. Antibodies
C. Cardiac glycosides
D. Lymph nodes
Question 18
Passive immunization is done for
A. tuberculosis
B. diphtheria
C. enteric fever
D. All of the above
Question 19
Which of the following expresses CD3 surface antigen?
A. Granulocytes
B. T cells
C. Monocytes
D. B cells
Question 20
Which is not an antigen-presenting cell (or APC)?
A. B cell
B. Polymorphonuclear leukocyte (or PMN)
C. Dendritic cell
D. All of the above
Question 21
Which of the following is most likely to produce anaphylaxis in a susceptible individual?
A. Pollen
B. Mold
C. Dust
D. Bee sting
Question 22
In animals, blood clots serve the function of
A. consuming invading organisms
B. helping them match the background coloration of the habitat
C. stimulating production of killer T lymphocytes
D. repairing damage to the body wall
Question 23
Which of these is part of the lymphoid system in humans?
A. Liver
B. Stomach
C. Tonsils
D. Kidneys
Question 24
What type of B cell remains dormant in the body, but can respond rapidly if the same antigen appears again?
A. T cells
B. Memory cells
C. Plasma cells
D. Macrophages
Question 25
Which of the following characteristics are common in lymphocytes, macrophages, and neutrophils?
A. They are all part of the nonspecific immune response in vertebrates
B. They are all part of the specific immune response in vertebrates
C. They are all part of the internal defenses of nonvertebrates
D. They are all types of white blood cells
Question 26
T cell receptors (or TCR) on CD4+ T cells
A. recognize peptides not associated with MHC molecules
B. recognize peptides associated with MHC class I molecules
C. recognize peptides associated with MHC class II molecules
D. are secreted out into the environment to bind antigens
Question 27
Natural killer cells are involved in
A. tumour rejection
B. allograft rejection
C. non-specific killing of virus transformed target cells
D. All of the above
Question 28
Numerous antibodies can be prepared, against one antigen, each binds to unique epitopes. How is this antibody diversity generated?
A. By rearrangements of the DNA encoding the variable regions of the heavy and light chains
B. By the combination of different heavy and light chains that form the antigen binding site
C. Antibody proteins can physically change their shape to bind different epitopes
D. Both A and B
Question 29
Large parasites such as helminthes may be killed extracellularly by the action of
A. basophils
B. monocytes
C. eosinophils
D. neutrophils
Question 30
Which of these is a type of specific defense against pathogens?
A. Lymphocytes
B. Macrophages
C. Phagocytes
D. Leukocytes
Question 31
Chemically an antigen may be
A. lipid
B. protein
C. polysaccharide
D. any of these
Question 32
Passive immunization is done for
A. tuberculosis
B. diphtheria
C. enteric fever
D. all of these
Question 33
CD8 surface antigen is present in
A. cytotoxic T cells
B. suppresssor T cells
C. Both A and B
D. None of these
Question 34
Cytotoxic T-cells can be recognized by which of the following cell surface marker?
A. CD4
B. CD7
C. CD8
D. CD9
Question 35
Which of the following components of the vertebrate immune response occurs first upon invasion by a virus or bacterium?
A. Activation of killer T lymphocytes
B. Activation of B lymphocytes
C. The inflammatory response
D. Mobilization of complement proteins
Question 36
Lack of reaction to our own human leukocyte antigens (HLAs) is known as?
A. autoimmunity
B. complement system
C. clonal selection
D. tolerance
Question 37
Macrophages are professional antigen- presenting cells. The protein molecule through which they present antigen in human is
A. actin
B. interleukin
C. HLA
D. CD8
Question 38
Which of the following proteins would not need localization signal?
A. A nuclear protein
B. A cytosolic protein
C. A protein bound to the endoplasmic reticulum (ER) membrane
D. A cell surface protein
Question 39
Natural killer cells are involved in
A. tumour rejection
B. allograft rejection
C. non-specific killing of virus transformed target cells
D. all of these
Question 40
Which of the following produces the antibodies employed in the specific immune response of vertebrates?
A. B lymphocytes
B. T lymphocytes
C. Neutrophils
D. Macrophages
Question 41
What type of B cell is like a tiny factory that produces antibodies identical to the B cell receptor that bind to the original antigen?
A. T cells
B. Memory cells
C. Plasma cells
D. Macrophages
Question 42
Immunity is not long lasting to
A. influenza
B. whooping cough
C. diphtheria
D. mumps
Question 43
Which of the following white blood cells act as scavengers when they engulf and digest pathogens?
A. Macrophages
B. T cells
C. B cells
D. Lymphocytes
Question 44
A cell which defends against body cells in which viruses are reproducing is
A. Exotoxin
B. Cytotoxic T cell
C. Endotoxin
D. Suppressor T cell
Question 45
The role of the M cell is to
A. trap virus in mucus and prevent entry
B. induce apoptosis in virus-infected small intestinal epithelia cells
C. pass bacteria or virus to underlying macrophages for processing and presentation of antigen
D. they use their cilia to propel mucus out of the small intestine
Question 46
The protein, produced by B cells that binds to a specific antigen is
A. phagocyte
B. leukocyte
C. vaccine
D. antibody
Question 47
Which of the following blood proteins can destroy pathogens?
A. Major histocompatibility complex
B. Platelets
C. Fibrinogen
D. Complement system
Question 48
Chemically an antigen may be
A. lipid
B. protein
C. polysaccharide
D. Any of the above
Question 49
What is the result of invasion of a body by pathogens?
A. Infection
B. Inflammation
C. Swelling
D. Pus
Question 50
Numerous antibodies can be prepared, against one antigen, each binds to unique epitopes. How is this antibody diversity generated?
A. By rearrangements of the DNA encoding the variable regions of the heavy and light chains
B. By the combination of different heavy and light chains that form the antigen binding site
C. Antibody proteins can physically change their shape to bind different epitopes
D. Both (a) and (b)