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Immune System MCQ Questions & Answers

Immune System MCQs : This section focuses on the "Immune System". These Multiple Choice Questions (MCQs) should be practiced to improve the Immune System skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

Cytotoxic T-cells can be recognized by which of the following cell surface marker?

A. CD4
B. CD7
C. CD8
D. CD9

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Question 2

What is the behavior in which T cells and B cells constantly travel throughout the body seeking out and destroying foreign substances?

A. Antibody-mediated immune response
B. Immune surveillance
C. Cell-mediated immune response
D. Vaccination

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Question 3

Which is not an antigen-presenting cell (or APC)?

A. B cell
B. Polymorphonuclear leukocyte (or PMN)
C. Dendritic cell
D. All of the above

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Question 4

T cell receptors (or TCR) on CD4+ T cells

A. recognize peptides not associated with MHC molecules
B. recognize peptides associated with MHC class I molecules
C. recognize peptides associated with MHC class II molecules
D. are secreted out into the environment to bind antigens

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Question 5

A cell which defends against body cells in which viruses are reproducing is

A. Exotoxin
B. Cytotoxic T cell
C. Endotoxin
D. Suppressor T cell

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Question 6

Which of the following expresses CD3 surface antigen?

A. Granulocytes
B. T cells
C. Monocytes
D. B cells

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Question 7

Numerous antibodies can be prepared, against one antigen, each binds to unique epitopes. How is this antibody diversity generated?

A. By rearrangements of the DNA encoding the variable regions of the heavy and light chains
B. By the combination of different heavy and light chains that form the antigen binding site
C. Antibody proteins can physically change their shape to bind different epitopes
D. Both A and B

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Question 8

Lack of reaction to our own human leukocyte antigens (HLAs) is known as?

A. autoimmunity
B. complement system
C. clonal selection
D. tolerance

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Question 9

Macrophages are professional antigen- presenting cells. The protein molecule through which they present antigen in human is

A. actin
B. interleukin
C. HLA
D. CD8

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Question 10

Which of the following(s) is/are the determinants of antigenicity?

A. Chemical nature
B. Size of the antigen
C. Foreignness
D. All of these

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Question 11

Chemically an antigen may be

A. lipid
B. protein
C. polysaccharide
D. Any of the above

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Question 12

Immunity is not long lasting to

A. influenza
B. whooping cough
C. diphtheria
D. mumps

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Question 13

Which of the following components of the vertebrate immune response occurs first upon invasion by a virus or bacterium?

A. Activation of killer T lymphocytes
B. Activation of B lymphocytes
C. The inflammatory response
D. Mobilization of complement proteins

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Question 14

Polymorphonuclear leukocytes (or PMNs)

A. can be attracted to the site of an infection following activation of complement
B. are derived from bone marrow stem cells
C. are a type of phagocyte that can engulf and kill bacteria
D. All of the above

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Question 15

Which of the following is correct for isoantigens?

A. They are antigens found in all members of different species
B. They are antigens found in some members of a species
C. They are antigens found in all members of a species
D. They are antigens found in some members of different species

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Question 16

Which of the following is not part of the vertebrate immune system?

A. Lymphocytes
B. Antibodies
C. Cardiac glycosides
D. Lymph nodes

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Question 17

Which of the following(s) is/are the determinants of antigenicity?

A. Chemical nature
B. Size of the antigen
C. Foreignness
D. All of the above

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Question 18

Treatment with bacterial endotoxins results blast formation in

A. B cells
B. T cells
C. monocytes
D. None of these

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Question 19

Natural killer cells are involved in

A. tumour rejection
B. allograft rejection
C. non-specific killing of virus transformed target cells
D. All of the above

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Question 20

The protein, produced by B cells that binds to a specific antigen is

A. phagocyte
B. leukocyte
C. vaccine
D. antibody

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Question 21

What type of B cell remains dormant in the body, but can respond rapidly if the same antigen appears again?

A. T cells
B. Memory cells
C. Plasma cells
D. Macrophages

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Question 22

Lysozyme is present in

A. sweat
B. Cerebro spinal fluid (CSF)
C. urine
D. saliva

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Question 23

Numerous antibodies can be prepared, against one antigen, each binds to unique epitopes. How is this antibody diversity generated?

A. By rearrangements of the DNA encoding the variable regions of the heavy and light chains
B. By the combination of different heavy and light chains that form the antigen binding site
C. Antibody proteins can physically change their shape to bind different epitopes
D. Both (a) and (b)

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Question 24

Which of the following is correct for CD8 T cells?

A. CD8 T cells only recognize virus-infected cells
B. CD8 T cell receptor recognizes epitopes that are also commonly recognized by B cells
C. In the thymus, CD8 T cells undergo positive selection only, whereas CD4 T cells undergo negative selection only
D. CD8 T cells can kill individual virus-infected cells in a contact dependent fashion

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Question 25

Passive immunization is done for

A. tuberculosis
B. diphtheria
C. enteric fever
D. all of these

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Question 26

Which of the following characteristics are common in lymphocytes, macrophages, and neutrophils?

A. They are all part of the nonspecific immune response in vertebrates
B. They are all part of the specific immune response in vertebrates
C. They are all part of the internal defenses of nonvertebrates
D. They are all types of white blood cells

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Question 27

Large parasites such as helminthes may be killed extracellularly by the action of

A. basophils
B. monocytes
C. eosinophils
D. neutrophils

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Question 28

CD8 surface antigen is present in

A. cytotoxic T cells
B. suppresssor T cells
C. both (a) and (b)
D. none of these

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Question 29

CD8 surface antigen is present in

A. cytotoxic T cells
B. suppresssor T cells
C. Both A and B
D. None of these

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Question 30

Which of the following proteins would not need localization signal?

A. A nuclear protein
B. A cytosolic protein
C. A protein bound to the endoplasmic reticulum (ER) membrane
D. A cell surface protein

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Question 31

Which of the following blood proteins can destroy pathogens?

A. Major histocompatibility complex
B. Platelets
C. Fibrinogen
D. Complement system

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Question 32

Which of the following is correct?

A. All T Cells are CD4+
B. An epitope can have multiple antigens
C. T Cell receptors are generated by random assortment of gene cassettes
D. MHC Class II molecules are generated by random assortment of gene cassettes

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Question 33

Which of these is a type of specific defense against pathogens?

A. Lymphocytes
B. Macrophages
C. Phagocytes
D. Leukocytes

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Question 34

Which of the following statements is false regarding B cells?

A. B cells can undergo class switching and produce a different antibody type
B. B one marrow stem cells migrate to the thymus and develop into B cells
C. B cells synthesize antibodies and put them on their cell surface
D. B cells that recognize high concentrations of antigens (self) in the absence of other signals undergo apoptosis in the bone marrow

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Question 35

Chemically an antigen may be

A. lipid
B. protein
C. polysaccharide
D. any of these

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Question 36

Passive immunization is done for

A. tuberculosis
B. diphtheria
C. enteric fever
D. All of the above

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Question 37

In animals, blood clots serve the function of

A. consuming invading organisms
B. helping them match the background coloration of the habitat
C. stimulating production of killer T lymphocytes
D. repairing damage to the body wall

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Question 38

In a fetus, where are lymphocytes produced?

A. In the spleen
B. In the bone marrow
C. In the liver
D. In the heart

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Question 39

Which of these is part of the lymphoid system in humans?

A. Liver
B. Stomach
C. Tonsils
D. Kidneys

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Question 40

Following are the defenses of the colon except

A. sIgA
B. fast flow rate
C. dense resident microbiota
D. mucus

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Question 41

What is the result of invasion of a body by pathogens?

A. Infection
B. Inflammation
C. Swelling
D. Pus

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Question 42

The role of the M cell is to

A. trap virus in mucus and prevent entry
B. induce apoptosis in virus-infected small intestinal epithelia cells
C. pass bacteria or virus to underlying macrophages for processing and presentation of antigen
D. they use their cilia to propel mucus out of the small intestine

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Question 43

Which of the following white blood cells act as scavengers when they engulf and digest pathogens?

A. Macrophages
B. T cells
C. B cells
D. Lymphocytes

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Question 44

Major Histo Compatibility Complex (MHC) is a collection of genes arrayed on

A. chromosome 21 in man, chromosome 6 in mice
B. chromosome 6 in man, chromosone 21 in mice
C. chromosome 17in man, chromosome 6 in mice
D. chromosome 6 in man, chromosome 17 in mice

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Question 45

Which of the following provide specific defense against viruses and bacteria?

A. T cells
B. B cells
C. Complement
D. inflammation

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Question 46

Natural killer cells are involved in

A. tumour rejection
B. allograft rejection
C. non-specific killing of virus transformed target cells
D. all of these

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Question 47

The maturation of T cells and the production of particular T cell receptors occurs in the

A. thyroid gland
B. thymus gland
C. testes
D. all of these

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Question 48

Which of the following is most likely to produce anaphylaxis in a susceptible individual?

A. Pollen
B. Mold
C. Dust
D. Bee sting

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Question 49

What type of B cell is like a tiny factory that produces antibodies identical to the B cell receptor that bind to the original antigen?

A. T cells
B. Memory cells
C. Plasma cells
D. Macrophages

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Question 50

Which of the following produces the antibodies employed in the specific immune response of vertebrates?

A. B lymphocytes
B. T lymphocytes
C. Neutrophils
D. Macrophages

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