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Monoclonal Antibodies MCQ Questions & Answers

Monoclonal Antibodies MCQs : This section focuses on the "Monoclonal Antibodies". These Multiple Choice Questions (MCQs) should be practiced to improve the Monoclonal Antibodies skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

It is highly valued if the lymphocytes derived from the lymph node or tonsil tend to undergo fusion at

A. high frequencies
B. moderate frequencies
C. low frequencies
D. at no frequency

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Question 2

A cytokine that stimulates the activity of B and T cells is

A. lymphotoxin
B. interlukin-2
C. interlukin-1
D. All of the above

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Question 3

TC cells are important in controlling

A. virus infections
B. allergy
C. autoimmunity
D. all of these

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Question 4

What is the method to harvest monoclonal antibodies from the positive clones?

A. Subculture in the new medium
B. Bioreactors
C. One a single media plate
D. Tissue culture method

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Question 5

Who invented the process of producing monoclonal antibodies in 1975?

A. Albert Einstein
B. Watson and Creek
C. Georges Köhler and César Milstein
D. Robert Hook

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Question 6

The Ig locus is about

A. 2/3rd of all hybridomas
B. l/3rd of all hybridomas
C. l/2nd of all hybridomas
D. 1/4th of all hybridomas

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Question 7

The hybrid cells can be propagated

A. in tissue culture
B. as ascites in peritoneal cavity of mice
C. both (a) and (b)
D. none of these

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Question 8

Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with

A. Ig MAbs
B. IgG
C. IgA
D. IgE

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Question 9

The cross linkage of antigens by antibodies is known as

A. agglutination
B. complement fixation
C. a cross reaction
D. all of these

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Question 10

The cross linkage of antigens by antibodies is known as

A. agglutination
B. complement fixation
C. a cross reaction
D. All of the above

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Question 11

The antigen-specific lymphocytes can be immortalized by which of the following method?

A. Transfection with tumor derived DNA
B. Hybridization with a suitable lymphoid tumor cell
C. Transformation following infection by Epstein-Barr virus (EB V)
D. All of the above

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Question 12

In immuno-inflammatory diseases such as hemolytic anaemia, eczema etc.,

A. T8 cells are greatly reduced
B. T8 cells are greatly increased
C. T4 cells are greatly reduced
D. T4 cells are greatly increased

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Question 13

Small simple molecules are

A. poor antigens
B. rich antigens
C. moderate antigens
D. heterophilic antigens

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Question 14

The primary B cell receptor is

A. IgD
B. IgG
C. IgA
D. IgE

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Question 15

The EBV-hybridoma technique

A. immortalizes the donor Bcells
B. facilitates the proliferation of antigen specific B cells
C. gives much higher hybridization frequencies
D. All of the above

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Question 16

What had helped the study of the structure of antibodies in 1970?

A. APC
B. Red blood cells
C. Killer cells
D. Cancer myeloma B-cell

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Question 17

Which type of cell actually secrets antibodies?

A. plasma cells
B. T cells
C. macrophages
D. dendritic cells

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Question 18

What do you add to Myeloma cells to receive HGPRT- myeloma cells?

A. 8 – Azaguanine
B. Azaguanine
C. Nitrogen flush
D. Carbon dioxide flush

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Question 19

Which of the following is incorrect?

A. MAbs can be used to diagnose or treat diseases
B. MAbs can be used in tumor scanning
C. MAbs canbe used in cancer diagnosis
D. MAbs can not be used in such non-infectious diseases as those of endocrine system

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Question 20

T cells are the source of

A. interleukin
B. interferon
C. lymphotoxin
D. All of the above

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Question 21

In human B cells and T cells are matured in the

A. bone marrow and thymus respectively
B. lymph nodes and spleen respectively
C. bursa and thymus respectively
D. None of the above

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Question 22

T cells are the source of

A. interleukin
B. interferon
C. lymphotoxin
D. all of these

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Question 23

What do we get when we fuse Spleen cells and Myeloma cells?

A. Hybridoma cells
B. Red blood cells
C. Killer cells
D. Cancer myeloma B-cell

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Question 24

Helper T cells assist in the functions of

A. certain B cells
B. certain T cells
C. certain B cells and other T cells
D. none of the above

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Question 25

Fight against Bioterrorism is one of the clinical applications of monoclonal antibodies.

A. True
B. False

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Question 26

What has become an important tool in biochemistry, molecular biology, and medicine?

A. DNA structure
B. Genome sequencing
C. MCA
D. PCR

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Question 27

Bispecific antibodies can bind with their Fab regions both to target antigen and to _____________

A. Other antibodies
B. An effector cell
C. Proteins around
D. Prostaglandins

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Question 28

Helper T cells assist in the functions of

A. certain B cells B
B. certain T cells
C. certain B cells and other T cells
D. None of the above

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Question 29

For which discovery did Georges Köhler and César Milstein share the noble prize in 1984?

A. Inventing genome sequencing
B. Discovery the structure of DNA
C. Discovery of B-cell cancer myeloma
D. Discovery of the process of producing monoclonal antibodies

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Question 30

The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

A. transformation of antigen specific B lymphocytes (EBV)
B. hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
C. combination of EB Vand hybridoma techniques
D. all of these

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Question 31

MAbs was modified for delivery of a toxin, radioisotope and __________

A. Enzymes
B. Hormones
C. Drugs
D. Cytokine

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Question 32

What is the clinical application of monoclonal antibodies?

A. Biosensors
B. Transplant rejection
C. Infectious disease
D. Purification of drugs

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Question 33

MCA are antibodies that are non-identical.

A. True
B. False

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Question 34

The cell fusion happens between spleen cells and _____________

A. Red blood cells
B. Cancer cell
C. Myeloma cells
D. Leukocytes

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Question 35

The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

A. transformation of antigen specific B lymphocytes (EBV)
B. hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
C. combination of EB Vand hybridoma techniques
D. All of the above

View Answer

Question 36

Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

A. absence of human immune response against murine proteins (HAMA) response
B. presence of HAMA response
C. poor recognition of immunoglobulin, Ig constant regions
D. All of the above

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Question 37

In human B cells and T cells are matured in the

A. bone marrow and thymus respectively
B. lymph nodes and spleen respectively
C. bursa and thymus respectively
D. none of these

View Answer

Question 38

In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a

A. hybridoma
B. myeloma
C. natural killer cell
D. lymphoblast

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Question 39

Which of the following is correct?

A. rabbits do not make myelomas whereas mice are unable to synthesize antibodies
B. rabbits do not make myelomas whereas mice are able to synthesize antibodies
C. rabbits make myelomas whereas mice are unable to synthesize antibodies
D. rabbits make myelomas whereas mice are able to synthesize antibodies

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Question 40

MAbs act directly when binding to cancer-specific antigens and induce an immunological response to cancer cells.

A. True
B. False

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Question 41

For how many weeks should you titer the Flow cytometry solution to get pure antigen?

A. 1 month
B. 3 weeks
C. 7 weeks
D. 2 weeks

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Question 42

A cytokine that stimulates the activity of B and T cells is

A. lymphotoxin
B. interlukin-2
C. interlukin-1
D. all of these

View Answer

Question 43

An example of mosaic antigen is

A. virus
B. bacteria
C. a hapten
D. protein

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Question 44

Biosensors & Microarrays are diagnostic applications of monoclonal antibodies.

A. True
B. False

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