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Monoclonal Antibodies MCQ Questions & Answers

Monoclonal Antibodies MCQs : This section focuses on the "Monoclonal Antibodies". These Multiple Choice Questions (MCQs) should be practiced to improve the Monoclonal Antibodies skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a

A. hybridoma
B. myeloma
C. natural killer cell
D. lymphoblast

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Question 2

MAbs act directly when binding to cancer-specific antigens and induce an immunological response to cancer cells.

A. True
B. False

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Question 3

Which of the following is incorrect?

A. MAbs can be used to diagnose or treat diseases
B. MAbs can be used in tumor scanning
C. MAbs canbe used in cancer diagnosis
D. MAbs can not be used in such non-infectious diseases as those of endocrine system

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Question 4

What do we get when we fuse Spleen cells and Myeloma cells?

A. Hybridoma cells
B. Red blood cells
C. Killer cells
D. Cancer myeloma B-cell

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Question 5

TC cells are important in controlling

A. virus infections
B. allergy
C. autoimmunity
D. all of these

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Question 6

The cell fusion happens between spleen cells and _____________

A. Red blood cells
B. Cancer cell
C. Myeloma cells
D. Leukocytes

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Question 7

Which of the following is correct?

A. rabbits do not make myelomas whereas mice are unable to synthesize antibodies
B. rabbits do not make myelomas whereas mice are able to synthesize antibodies
C. rabbits make myelomas whereas mice are unable to synthesize antibodies
D. rabbits make myelomas whereas mice are able to synthesize antibodies

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Question 8

MCA are antibodies that are non-identical.

A. True
B. False

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Question 9

What do you add to Myeloma cells to receive HGPRT- myeloma cells?

A. 8 – Azaguanine
B. Azaguanine
C. Nitrogen flush
D. Carbon dioxide flush

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Question 10

The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

A. transformation of antigen specific B lymphocytes (EBV)
B. hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
C. combination of EB Vand hybridoma techniques
D. all of these

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Question 11

The Ig locus is about

A. 2/3rd of all hybridomas
B. l/3rd of all hybridomas
C. l/2nd of all hybridomas
D. 1/4th of all hybridomas

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Question 12

Small simple molecules are

A. poor antigens
B. rich antigens
C. moderate antigens
D. heterophilic antigens

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Question 13

Helper T cells assist in the functions of

A. certain B cells B
B. certain T cells
C. certain B cells and other T cells
D. None of the above

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Question 14

It is highly valued if the lymphocytes derived from the lymph node or tonsil tend to undergo fusion at

A. high frequencies
B. moderate frequencies
C. low frequencies
D. at no frequency

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Question 15

T cells are the source of

A. interleukin
B. interferon
C. lymphotoxin
D. All of the above

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Question 16

What has become an important tool in biochemistry, molecular biology, and medicine?

A. DNA structure
B. Genome sequencing
C. MCA
D. PCR

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Question 17

Biosensors & Microarrays are diagnostic applications of monoclonal antibodies.

A. True
B. False

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Question 18

The cross linkage of antigens by antibodies is known as

A. agglutination
B. complement fixation
C. a cross reaction
D. All of the above

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Question 19

The EBV-hybridoma technique

A. immortalizes the donor Bcells
B. facilitates the proliferation of antigen specific B cells
C. gives much higher hybridization frequencies
D. All of the above

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Question 20

Who invented the process of producing monoclonal antibodies in 1975?

A. Albert Einstein
B. Watson and Creek
C. Georges Köhler and César Milstein
D. Robert Hook

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Question 21

What is the method to harvest monoclonal antibodies from the positive clones?

A. Subculture in the new medium
B. Bioreactors
C. One a single media plate
D. Tissue culture method

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Question 22

Fight against Bioterrorism is one of the clinical applications of monoclonal antibodies.

A. True
B. False

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Question 23

Which type of cell actually secrets antibodies?

A. plasma cells
B. T cells
C. macrophages
D. dendritic cells

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Question 24

For which discovery did Georges Köhler and César Milstein share the noble prize in 1984?

A. Inventing genome sequencing
B. Discovery the structure of DNA
C. Discovery of B-cell cancer myeloma
D. Discovery of the process of producing monoclonal antibodies

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Question 25

The antigen-specific lymphocytes can be immortalized by which of the following method?

A. Transfection with tumor derived DNA
B. Hybridization with a suitable lymphoid tumor cell
C. Transformation following infection by Epstein-Barr virus (EB V)
D. All of the above

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Question 26

In immuno-inflammatory diseases such as hemolytic anaemia, eczema etc.,

A. T8 cells are greatly reduced
B. T8 cells are greatly increased
C. T4 cells are greatly reduced
D. T4 cells are greatly increased

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Question 27

MAbs was modified for delivery of a toxin, radioisotope and __________

A. Enzymes
B. Hormones
C. Drugs
D. Cytokine

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Question 28

In human B cells and T cells are matured in the

A. bone marrow and thymus respectively
B. lymph nodes and spleen respectively
C. bursa and thymus respectively
D. none of these

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Question 29

An example of mosaic antigen is

A. virus
B. bacteria
C. a hapten
D. protein

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Question 30

In human B cells and T cells are matured in the

A. bone marrow and thymus respectively
B. lymph nodes and spleen respectively
C. bursa and thymus respectively
D. None of the above

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Question 31

What is the clinical application of monoclonal antibodies?

A. Biosensors
B. Transplant rejection
C. Infectious disease
D. Purification of drugs

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Question 32

Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

A. absence of human immune response against murine proteins (HAMA) response
B. presence of HAMA response
C. poor recognition of immunoglobulin, Ig constant regions
D. All of the above

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Question 33

For how many weeks should you titer the Flow cytometry solution to get pure antigen?

A. 1 month
B. 3 weeks
C. 7 weeks
D. 2 weeks

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Question 34

What had helped the study of the structure of antibodies in 1970?

A. APC
B. Red blood cells
C. Killer cells
D. Cancer myeloma B-cell

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Question 35

The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

A. transformation of antigen specific B lymphocytes (EBV)
B. hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
C. combination of EB Vand hybridoma techniques
D. All of the above

View Answer

Question 36

Bispecific antibodies can bind with their Fab regions both to target antigen and to _____________

A. Other antibodies
B. An effector cell
C. Proteins around
D. Prostaglandins

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Question 37

The hybrid cells can be propagated

A. in tissue culture
B. as ascites in peritoneal cavity of mice
C. both (a) and (b)
D. none of these

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Question 38

T cells are the source of

A. interleukin
B. interferon
C. lymphotoxin
D. all of these

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Question 39

Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with

A. Ig MAbs
B. IgG
C. IgA
D. IgE

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Question 40

A cytokine that stimulates the activity of B and T cells is

A. lymphotoxin
B. interlukin-2
C. interlukin-1
D. All of the above

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Question 41

Helper T cells assist in the functions of

A. certain B cells
B. certain T cells
C. certain B cells and other T cells
D. none of the above

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Question 42

The cross linkage of antigens by antibodies is known as

A. agglutination
B. complement fixation
C. a cross reaction
D. all of these

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Question 43

The primary B cell receptor is

A. IgD
B. IgG
C. IgA
D. IgE

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Question 44

A cytokine that stimulates the activity of B and T cells is

A. lymphotoxin
B. interlukin-2
C. interlukin-1
D. all of these

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