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Transcription MCQ Questions & Answers

Transcription MCQs : This section focuses on the "Transcription". These Multiple Choice Questions (MCQs) should be practiced to improve the Transcription skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

Which of the following is TRUE for the RNA polymerase activity?

A. DNA dependent DNA synthesis
B. Direct repair
C. DNA dependent RNA synthesis
D. RNA dependent RNA synthesis

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Question 2

Which of the following component of RNA polymerase facilitates the recognition of promoter sequences?

A. a subunit
B. b subunit
C. s subunit
D. c subunit

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Question 3

Which of these catalyzes the synthesis of RNA from a DNA template?

A. DNA gyrase
B. DNA ligase
C. DNA polymerase
D. RNA polymerase

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Question 4

Mark the one, which is NOT the transcription inhibitor in eukaryotes.

A. Rifampicin
B. Acridine dye
C. Actinomycin D
D. Rho factor

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Question 5

Which of the following enzymes are used in the process of transcription?

A. DNA polymerases
B. RNA polymerases
C. DNA helicase
D. DNA topoisomerase

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Question 6

The transcription factors assist the RNA polymerase in locating ________________

A. stop codon
B. mutation
C. active site
D. promoter

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Question 7

A level of regulation, demonstrated by the termination of transcription if tryptophan is abundant, by the tryptophan operon in E.coli cells is called

A. activation
B. attenuation
C. corepression
D. desiccation

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Question 8

Which of the following proteins first binds to TATA box during transcription?

A. TF II A
B. TF II D
C. TF II B
D. RNA polymerase

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Question 9

A specific __________ factor helps RNA polymerase bind to late promoters and transcribe late genes.

A. sigma
B. beta
C. delta
D. gamma

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Question 10

After transcribing into RNA, the gene is spliced out of the genome.

A. True
B. False

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Question 11

What is the work of the sigma factor in transcription?

A. Helicase action
B. Transcription initiation
C. Transcription elongation
D. Transcription termination

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Question 12

Which of the following play a role in structural support?

A. rRNA
B. mRNA
C. tDNA
D. tRNA

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Question 13

Which of the following transcription termination technique has RNA dependent ATPase activity?

A. Intercalating agents
B. Rho dependent
C. Rho independent
D. Rifampcin

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Question 14

RNA is a mobile nucleic acid.

A. True
B. False

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Question 15

Name the sigma factor which is used for promoter recognition?

A. Sigma 32
B. Sigma 70
C. Sigma 60
D. Sigma 40

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Question 16

Which of the following is a product of transcription?

A. mRNA
B. tRNA
C. rRNA
D. all of these

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Question 17

Which enzyme makes the transcription, an essentially irreversible process?

A. pyrophosphatase
B. amylase
C. glucamylase
D. topoisomerase

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Question 18

The process of formation of RNA is known as___________

A. Replication
B. DNA repair
C. Translation
D. Transcription

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Question 19

Which eukaryotic RNA polymerase makes tRNA's?

A. RNA polymerase 1
B. RNA polymerase 2
C. RNA polymerase 3
D. Any of these

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Question 20

What is the usual sequence of a Pribnow box?

A. AUAUA
B. TATAAT
C. UUUUU
D. TTGACA

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Question 21

Recognition/binding site of RNA polymerase is called

A. receptor
B. promoter
C. facilitator
D. terminator

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Question 22

Like replication, transcription also occurs bidirectionally.

A. True
B. False

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Question 23

Transcription is the synthesis of ______________________

A. RNA
B. DNA
C. Protein
D. Polypeptide

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Question 24

Which eukaryotic RNA polymerase makes tRNA's?

A. RNA polymerase 1
B. RNA polymerase 2
C. RNA polymerase 3
D. Any of the above

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Question 25

In patients of sickle cell anemia, the hemoglobin contains a substitution for ____________________

A. glutamic acid
B. ascorbic acid
C. carboxylic acid
D. quinone

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Question 26

Which of the following enzyme(s) is/are required for lactose fermentation?

A. Transacetylase
B. β-galactosidase
C. Galactoside permease
D. All of the above

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Question 27

What is the intermediate between a gene and its polypeptide?

A. mRNA
B. tRNA
C. rRNA
D. siRNA

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Question 28

When was the link between enzymes and inherited disease first elucidated?

A. 1708
B. 1808
C. 1908
D. 2008

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Question 29

Name the site where upstream sequences located?

A. Prior to start point
B. After the startpoint
C. Right border of DNA
D. In the middle of DNA

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Question 30

Which of the following ensure stable binding of RNA polymerase at the promoter site?

A. DNA photolyase
B. Sigma factor
C. DNA glycosylase
D. RecA

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Question 31

The sigma factor

A. is responsible for recognizing the termination sequence
B. provides the catalytic function of cleaving off pyrophosphates during mRNA synthesis
C. recognizes the promotor
D. accomplishes DNA restriction

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Question 32

An mRNA transcript of a gene contains

A. a start codon
B. a stop codon
C. a terminator
D. All of the above

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Question 33

Which of the following statement defines a replicon?

A. A DNA molecule that encodes pili for conjugation
B. A DNA molecule that is able to replicate and be maintained
C. A DNA template which is used in transcription
D. The enzyme responsible for transposition

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Question 34

Name the one intrinsic terminator of transcription.

A. Intercalating agents
B. Rho independent
C. Rho dependent
D. Acridine orange

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Question 35

The components found in all prokaryotic transcription terminators is

A. a poly-U region
B. Rho factor
C. a hairpin structure
D. None of these

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Question 36

Mark the statement which is INCORRECT about the transcription unit?

A. It is a transcribed segment of DNA
B. Eukaryotes have monocistronic transcription unit
C. Prokaryotes also have a monocistronic transcription unit
D. Immediate product of transcription is primary transcript

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Question 37

Which of the following enzyme is used for synthesis of RNA under the direction of DNA?

A. RNA polymerase
B. DNA ligase
C. DNA polymerase
D. RNA ligase

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Question 38

An mRNA transcript of a gene contains

A. a start codon
B. a stop codon
C. a terminator
D. all of these

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Question 39

Which of the following is used to describe the time taken by RNA polymerase to leave the promoter?

A. Promoter clearance time
B. Abortive initiation
C. Elongation factor
D. Mean time

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Question 40

How many base pairs of DNA is transcribed by RNA polymerase in one go?

A. 5-6
B. 3
C. 4
D. 7-8

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Question 41

In bacteria, binding of _________ factor to the RNA polymerase increases its affinity for promoter sites in the DNA.

A. alpha
B. sigma
C. rho
D. beta

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Question 42

Promoter is a ____________________

A. gene
B. site on DNA
C. site on RNA
D. toxin

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Question 43

Which of the following is a product of transcription?

A. mRNA
B. tRNA
C. rRNA
D. All of the above

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Question 44

Which proteolytic enzyme was used in the experiments aimed at elucidating the mutation that causes sickle cell anemia?

A. papain
B. rennin
C. pepsin
D. trypsin

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Question 45

Which of the two strands of DNA will be transcribed is determined by the _______________

A. RNA polymerase
B. DNA polymerase
C. Promoter sequence
D. Inducer sequence

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Question 46

The synthesis of mRNA based on a DNA template is called

A. DNA replication
B. transcription
C. translation
D. DNA restriction

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Question 47

Which organism was used for experiments that led to “one gene – one enzyme” hypothesis?

A. Neurospora
B. Nematode
C. Mus musculus
D. Drosophila

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Question 48

The location of first hexameric sequence typically found in pro-karyotic promoters is

A. at the transcription start site
B. approximately 35 bases upstream of the transcription start site
C. approximately 10 bases upstream of the transcription start site
D. approximately 25 bases upstream of the transcription start site

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Question 49

Which of the following enzyme(s) is/are required for lactose fermentation?

A. Transacetylase
B. β-galactosidase
C. Galactoside permease
D. All of these

View Answer