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Translation and Regulation MCQ Questions & Answers

Translation and Regulation MCQs : This section focuses on the "Translation and Regulation". These Multiple Choice Questions (MCQs) should be practiced to improve the Translation and Regulation skills required for various interviews (campus interview, walk-in interview, company interview), placement, entrance exam and other competitive examinations.




Question 1

Which of the following statement is correct?

A. The size and sequence of introns can be deduced from the cDNA sequence
B. Restriction endonuclease can cleave ss and dsDNA both
C. Restriction fragment length polymorphism (RFLP) is usually formed in coding sequence of a gene
D. Amino acid sequence of a protein can be deduced from corresponding cDNA nucleotide

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Question 2

The interaction between the mRNA and tRNA determined the position of amino acid in a polypeptide sequence. This is called the

A. stagerivity
B. Wobble hypothesis
C. promiscuity
D. adaptor hypothesis

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Question 3

What was the first bacterial genome to be sequenced and made public?

A. Bacillus subtilis
B. Escherichia coli
C. Haemophilus influenzae
D. No bacterial genome has been sequenced yet

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Question 4

Negative regulation of protein synthesis is accomplished by

A. allosteric inhibition
B. the binding of RNA polymerase to the promoter
C. the binding of a repressor to the DNA
D. the binding of a repressor to the RNA polymerase

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Question 5

What is the direct cause of cell death by diphtheria toxin?

A. Formation of an ion channel in the cell membrane
B. Inactivation of a translational elongation factor
C. Induction of apoptosis
D. None of the above

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Question 6

The development of global regulatory systems in prokaryotes

A. determines the exact location of the cell on the globe
B. aids in DNA replication
C. determines the exact location of the replication site
D. regulates many genes under varying environmental conditions

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Question 7

The nonsense codon(s) is/are

A. UAG
B. UAA
C. UGA
D. all of these

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Question 8

During amino acid activation a(n)

A. amino acid is bound to tRNA
B. amino acid is bound to mRNA
C. methyl group is attached to rRNA
D. methyl group is attached to an amino acid

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Question 9

What is the action of tetracycline in prokaryotes?

A. It blocks translocation reaction on ribosomes
B. It blocks peptidyl transferase reaction on ribosomes
C. It blocks the binding of amino-acyl tRNA to the A site of ribosomes
D. Not known with certainity

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Question 10

Site in the ribosome from which the tRNA donates amino acids to the growing polypeptide chain is

A. P site
B. O site
C. T site
D. A site

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Question 11

Which of the following modified amino acid is used at the starting of most prokaryotic proteins?

A. N-formylserine
B. N-formylmethionine
C. N-formylleucine
D. N-formylalanine

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Question 12

Which of the following three codons translate as serine (Ser)?

A. AGU
B. CGA
C. CAU
D. AUG

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Question 13

Which stop codon has been found to encode selenocysteine?

A. UAA
B. UAG
C. UGA
D. AGA

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Question 14

Which of the following act as the blueprint or template for the process of protein synthesis that takes place on ribosomes?

A. rRNA
B. DNA
C. tRNA
D. mRNA

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Question 15

Which of the following is a nontranslated sequence located between the transcription and the translation start site?

A. Ending frame
B. Leader sequence
C. Trailer sequence
D. Reading frame

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Question 16

Which of the following defines an open reading frame (ORF)?

A. A sequence of genome in bacteriophage
B. The sequence of a complete genome
C. A plasmid vector used in genome sequencing
D. A possible gene predicted by DNA sequencing

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Question 17

The ribosome binding site

A. forms a stem-loop structure in the RNA
B. is located upstream of the promoter sequence
C. is located immediately upstream of the start codon
D. is more likely to be associated with an operon than with a gene encoding a single protein

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Question 18

A quorum sensing system

A. detects a signal from the external environment
B. senses a compound produced by the bacterium itself
C. consists of a sensor component that phosphorylates a regulatory protein
D. controls the activity of ribosomes directly

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Question 19

What is the direct cause of cell death by diphtheria toxin?

A. Formation of an ion channel in the cell membrane
B. Inactivation of a translational elongation factor
C. Induction of apoptosis
D. None of these

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Question 20

Which of the termination codon is called amber?

A. UAA
B. UAG
C. UGA
D. AUG

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Question 21

The final step of gene expression is protein synthesis, which is also known as

A. replication
B. translation
C. transcription
D. None of these

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Question 22

Which of the following molecule catalyzes the transpeptidation reaction?

A. RNA polymerase
B. Peptidyl transferase
C. DNA ligase
D. DNA polymerase

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Question 23

Which binding is inhibited by pactamycin?

A. Aminoacyl-tRNA to the A-site of 30S subunit
B. Initiator-tRNA to 30S/40S initiation complexes
C. Peptidyl t-RNA to the 50S subunit
D. Formation of peptide bond in P site

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Question 24

The Shine-Dalgarno sequence is

A. trailer sequence
B. a stop codon
C. the reading frame of a gene
D. a short sequence that acts as a ribosomal binding site

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Question 25

Three stop codons, which aids in termination of translation are also known as

A. pause codons
B. nonsense codons
C. missense codons
D. antisense codons

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Question 26

When was the genetic code completed?

A. 1958
B. 1952
C. 1966
D. 1968

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Question 27

The role of molecular chaperones is to

A. facilitate binding of ribosomes to mRNA
B. degrade newly synthesized polypeptides that contain inaccurate sequences
C. facilitate binding of RNA polymerase to DNA
D. aid a newly synthesized polypeptide in folding to its proper shape

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Question 28

What is the maximum number of different amino acids in a polypeptide chain coded by the synthetic polyribonucleotides (UCAG)5?

A. One
B. Two
C. Three
D. Four

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Question 29

What are the Svedberg values for the subunits of the 70S ribosomes of E. colli?

A. 40S and 30S
B. 50S and 20S
C. 50S and 30S
D. 40S and 20S

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Question 30

Which phage always carries a small piece of E.coli genome?

A. Lambda
B. Mu
C. T4
D. T3

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Question 31

The nonsense codon(s) is/are

A. UAG
B. UAA
C. UGA
D. All of the above

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